Oncocytic variant of medullary thyroid carcinoma - a case report

Research output: Contribution to journalArticle

Abstract

Medullary thyroid carcinoma (MTC) is a rare tumor arising from parafollicular C-cells. The oncocytic variant of MTC is an extremely rare diagnosis, with less than 20 cases reported. Here we present the case of a 36-year-old male patient with complaints of neck swelling and dysphagia. On fine needle aspiration cytology (FNAC), a Hürthle cell neoplasm was suggested. Finally with histopathology and immunohistochemistry (IHC), a diagnosis of MTC oncocytic variant was established. This tumor can be easily misdiagnosed for any thyroid Hürthle cell lesions. An accurate diagnosis is important because MTC has different treatment protocols, and its oncocytic variant is expected to be associated with poorer patient survival. Thus, the oncocytic variant of MTC is a difficult diagnosis on FNAC. Histopathology and relevant IHC markers are necessary for a correct diagnosis.

Original languageEnglish
Pages (from-to)83-86
Number of pages4
JournalIranian Journal of Pathology
Volume14
Issue number1
DOIs
Publication statusPublished - 01-01-2019

Fingerprint

Fine Needle Biopsy
Cell Biology
Immunohistochemistry
Neoplasms
Deglutition Disorders
Clinical Protocols
Diagnostic Errors
Thyroid Gland
Neck
Medullary Thyroid cancer
Survival

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

@article{100532549c684c97a52f3f16dfb90145,
title = "Oncocytic variant of medullary thyroid carcinoma - a case report",
abstract = "Medullary thyroid carcinoma (MTC) is a rare tumor arising from parafollicular C-cells. The oncocytic variant of MTC is an extremely rare diagnosis, with less than 20 cases reported. Here we present the case of a 36-year-old male patient with complaints of neck swelling and dysphagia. On fine needle aspiration cytology (FNAC), a H{\"u}rthle cell neoplasm was suggested. Finally with histopathology and immunohistochemistry (IHC), a diagnosis of MTC oncocytic variant was established. This tumor can be easily misdiagnosed for any thyroid H{\"u}rthle cell lesions. An accurate diagnosis is important because MTC has different treatment protocols, and its oncocytic variant is expected to be associated with poorer patient survival. Thus, the oncocytic variant of MTC is a difficult diagnosis on FNAC. Histopathology and relevant IHC markers are necessary for a correct diagnosis.",
author = "Srinivas, {Srilatha Parampalli} and Jayitri Das and Vidya Monappa",
year = "2019",
month = "1",
day = "1",
doi = "10.30699/IJP.14.1.83",
language = "English",
volume = "14",
pages = "83--86",
journal = "Iranian Journal of Pathology",
issn = "1735-5303",
publisher = "Iranian Society of Pathology",
number = "1",

}

Oncocytic variant of medullary thyroid carcinoma - a case report. / Srinivas, Srilatha Parampalli; Das, Jayitri; Monappa, Vidya.

In: Iranian Journal of Pathology, Vol. 14, No. 1, 01.01.2019, p. 83-86.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Oncocytic variant of medullary thyroid carcinoma - a case report

AU - Srinivas, Srilatha Parampalli

AU - Das, Jayitri

AU - Monappa, Vidya

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Medullary thyroid carcinoma (MTC) is a rare tumor arising from parafollicular C-cells. The oncocytic variant of MTC is an extremely rare diagnosis, with less than 20 cases reported. Here we present the case of a 36-year-old male patient with complaints of neck swelling and dysphagia. On fine needle aspiration cytology (FNAC), a Hürthle cell neoplasm was suggested. Finally with histopathology and immunohistochemistry (IHC), a diagnosis of MTC oncocytic variant was established. This tumor can be easily misdiagnosed for any thyroid Hürthle cell lesions. An accurate diagnosis is important because MTC has different treatment protocols, and its oncocytic variant is expected to be associated with poorer patient survival. Thus, the oncocytic variant of MTC is a difficult diagnosis on FNAC. Histopathology and relevant IHC markers are necessary for a correct diagnosis.

AB - Medullary thyroid carcinoma (MTC) is a rare tumor arising from parafollicular C-cells. The oncocytic variant of MTC is an extremely rare diagnosis, with less than 20 cases reported. Here we present the case of a 36-year-old male patient with complaints of neck swelling and dysphagia. On fine needle aspiration cytology (FNAC), a Hürthle cell neoplasm was suggested. Finally with histopathology and immunohistochemistry (IHC), a diagnosis of MTC oncocytic variant was established. This tumor can be easily misdiagnosed for any thyroid Hürthle cell lesions. An accurate diagnosis is important because MTC has different treatment protocols, and its oncocytic variant is expected to be associated with poorer patient survival. Thus, the oncocytic variant of MTC is a difficult diagnosis on FNAC. Histopathology and relevant IHC markers are necessary for a correct diagnosis.

UR - http://www.scopus.com/inward/record.url?scp=85061907363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061907363&partnerID=8YFLogxK

U2 - 10.30699/IJP.14.1.83

DO - 10.30699/IJP.14.1.83

M3 - Article

VL - 14

SP - 83

EP - 86

JO - Iranian Journal of Pathology

JF - Iranian Journal of Pathology

SN - 1735-5303

IS - 1

ER -