One-pot synthesis of pyrimidinothiazolidinones and their anti-inflammatory and antimicrobial studies

B. Lingappa, K. V. Sujith, Adithya Adhikari, N. Satheesha Rai, K. Vijaynarayana, Balakrishna Kalluraya

Research output: Contribution to journalArticle

Abstract

In the present investigation, we report a one-pot synthesis of the title compounds, 2-arylidene-5-(2,3,6-trimethyl-4-methoxyphenyl)-7-substituted-5H- pyrimidino-[2,3-b]thiazolidine-3-ones 6a-j and 2-(5-nitro-2-thienylidine)-5-(2, 3,6-trimethyl-4-methoxyphenyl)-7-substituted-5H- pyrimidino-[2,3-b]thiazolidine- 3-ones 7a-e. Thus, 6a-j and 7a-e were prepared in good yields by refluxing 4-(2,3,6-trimethyl-4-methoxyphenyl)-6-methyl/aryl-3,4-dihydropyrimidin-2-(1H) -thiones 5, monochloro acetic acid, and anhydrous sodium acetate with the appropriate aromatic aldehyde/5-nitro-2-thiophenediacetate in acetic acid/acetic anhydride medium. The structures of these new compounds were established on the basis of their analytical and spectral data. Some of the newly synthesized compounds were screened for their anti-inflammatory and antimicrobial activity. They show moderate anti-inflammatory activity, and some of them were found to be promising antibacterial and antifungal agents. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.

Original languageEnglish
Pages (from-to)501-508
Number of pages8
JournalPhosphorus, Sulfur and Silicon and the Related Elements
Volume185
Issue number3
DOIs
Publication statusPublished - 03-2010

All Science Journal Classification (ASJC) codes

  • Inorganic Chemistry
  • Organic Chemistry
  • Biochemistry

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