One-pot synthesis of pyrimidinothiazolidinones and their anti-inflammatory and antimicrobial studies

B. Lingappa, K. V. Sujith, Adithya Adhikari, N. Satheesha Rai, K. Vijaynarayana, Balakrishna Kalluraya

Research output: Contribution to journalArticle

Abstract

In the present investigation, we report a one-pot synthesis of the title compounds, 2-arylidene-5-(2,3,6-trimethyl-4-methoxyphenyl)-7-substituted-5H- pyrimidino-[2,3-b]thiazolidine-3-ones 6a-j and 2-(5-nitro-2-thienylidine)-5-(2, 3,6-trimethyl-4-methoxyphenyl)-7-substituted-5H- pyrimidino-[2,3-b]thiazolidine- 3-ones 7a-e. Thus, 6a-j and 7a-e were prepared in good yields by refluxing 4-(2,3,6-trimethyl-4-methoxyphenyl)-6-methyl/aryl-3,4-dihydropyrimidin-2-(1H) -thiones 5, monochloro acetic acid, and anhydrous sodium acetate with the appropriate aromatic aldehyde/5-nitro-2-thiophenediacetate in acetic acid/acetic anhydride medium. The structures of these new compounds were established on the basis of their analytical and spectral data. Some of the newly synthesized compounds were screened for their anti-inflammatory and antimicrobial activity. They show moderate anti-inflammatory activity, and some of them were found to be promising antibacterial and antifungal agents. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.

Original languageEnglish
Pages (from-to)501-508
Number of pages8
JournalPhosphorus, Sulfur and Silicon and the Related Elements
Volume185
Issue number3
DOIs
Publication statusPublished - 03-2010

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Thiazolidines
Acetic Acid
Anti-Inflammatory Agents
Thiones
Sodium Acetate
Antifungal Agents
Silicon
Sulfur
Aldehydes
Phosphorus
Anti-Bacterial Agents
acetic anhydride

All Science Journal Classification (ASJC) codes

  • Inorganic Chemistry
  • Organic Chemistry
  • Biochemistry

Cite this

Lingappa, B. ; Sujith, K. V. ; Adhikari, Adithya ; Rai, N. Satheesha ; Vijaynarayana, K. ; Kalluraya, Balakrishna. / One-pot synthesis of pyrimidinothiazolidinones and their anti-inflammatory and antimicrobial studies. In: Phosphorus, Sulfur and Silicon and the Related Elements. 2010 ; Vol. 185, No. 3. pp. 501-508.
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One-pot synthesis of pyrimidinothiazolidinones and their anti-inflammatory and antimicrobial studies. / Lingappa, B.; Sujith, K. V.; Adhikari, Adithya; Rai, N. Satheesha; Vijaynarayana, K.; Kalluraya, Balakrishna.

In: Phosphorus, Sulfur and Silicon and the Related Elements, Vol. 185, No. 3, 03.2010, p. 501-508.

Research output: Contribution to journalArticle

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AU - Lingappa, B.

AU - Sujith, K. V.

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