Oocyte retrieval at 140-mmHg negative aspiration pressure

A promising alternative to flushing and aspiration in assisted reproduction in women with low ovarian reserve

Aswathy Kumaran, Pratap Narayan, Praveena Pai, Amar Ramachandran, Basil Mathews, Satish Adiga

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Oocyte retrieval in women with low ovarian reserve is challenging and often results in poor pregnancy outcomes. Aim: The aim was to compare outcomes of oocyte retrieval using three aspiration methods in women with normal and low antral follicle counts (AFCs). Study Design: Retrospective cohort study. Setting: Tertiary care hospital. Materials and Methods: Data from 172 women who underwent in-vitro fertilization/intracytoplasmic sperm injection over 3 years was studied after dividing into three groups: Group A (96)-normal AFC (≥10), direct oocyte retrieval at 120 mmHg, Group B (41)-low AFC (<10), direct retrieval at 140-mmHg, Group C (35)-low AFC, follicular flushing, and aspiration at 120-mmHg. In each group, oocyte yield, embryo quality, and pregnancy out comes were assessed. Results: The oocyte and embryo yield in Groups A and B were comparable (P > 0.05) but were significantly less in Group C (P < 0.05). The pregnancy rates in Groups A and B were similar (35.4%, 39%) but were significantly less (17.1%) in Group C (P < 0.05). The live birth rate was 76% in Group A, 69% in Group B, and 50% in Group C. The miscarriage rates in the three groups were 21%, 31%, and 50%, respectively. Conclusion: Direct oocyte retrieval with 140-mmHg showed significantly better oocyte yield and pregnancy outcomes compared to flushing and aspiration in women with low AFC.

Original languageEnglish
Pages (from-to)98-102
Number of pages5
JournalJournal of Human Reproductive Sciences
Volume8
Issue number2
DOIs
Publication statusPublished - 01-04-2015

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Oocyte Retrieval
Reproduction
Pressure
Pregnancy Outcome
Intracytoplasmic Sperm Injections
Birth Rate
Live Birth
Spontaneous Abortion
Tertiary Healthcare
Pregnancy Rate
Fertilization in Vitro
Tertiary Care Centers
Oocytes
Cohort Studies
Retrospective Studies
Ovarian Reserve
Antral

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine

Cite this

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title = "Oocyte retrieval at 140-mmHg negative aspiration pressure: A promising alternative to flushing and aspiration in assisted reproduction in women with low ovarian reserve",
abstract = "Oocyte retrieval in women with low ovarian reserve is challenging and often results in poor pregnancy outcomes. Aim: The aim was to compare outcomes of oocyte retrieval using three aspiration methods in women with normal and low antral follicle counts (AFCs). Study Design: Retrospective cohort study. Setting: Tertiary care hospital. Materials and Methods: Data from 172 women who underwent in-vitro fertilization/intracytoplasmic sperm injection over 3 years was studied after dividing into three groups: Group A (96)-normal AFC (≥10), direct oocyte retrieval at 120 mmHg, Group B (41)-low AFC (<10), direct retrieval at 140-mmHg, Group C (35)-low AFC, follicular flushing, and aspiration at 120-mmHg. In each group, oocyte yield, embryo quality, and pregnancy out comes were assessed. Results: The oocyte and embryo yield in Groups A and B were comparable (P > 0.05) but were significantly less in Group C (P < 0.05). The pregnancy rates in Groups A and B were similar (35.4{\%}, 39{\%}) but were significantly less (17.1{\%}) in Group C (P < 0.05). The live birth rate was 76{\%} in Group A, 69{\%} in Group B, and 50{\%} in Group C. The miscarriage rates in the three groups were 21{\%}, 31{\%}, and 50{\%}, respectively. Conclusion: Direct oocyte retrieval with 140-mmHg showed significantly better oocyte yield and pregnancy outcomes compared to flushing and aspiration in women with low AFC.",
author = "Aswathy Kumaran and Pratap Narayan and Praveena Pai and Amar Ramachandran and Basil Mathews and Satish Adiga",
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T1 - Oocyte retrieval at 140-mmHg negative aspiration pressure

T2 - A promising alternative to flushing and aspiration in assisted reproduction in women with low ovarian reserve

AU - Kumaran, Aswathy

AU - Narayan, Pratap

AU - Pai, Praveena

AU - Ramachandran, Amar

AU - Mathews, Basil

AU - Adiga, Satish

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Oocyte retrieval in women with low ovarian reserve is challenging and often results in poor pregnancy outcomes. Aim: The aim was to compare outcomes of oocyte retrieval using three aspiration methods in women with normal and low antral follicle counts (AFCs). Study Design: Retrospective cohort study. Setting: Tertiary care hospital. Materials and Methods: Data from 172 women who underwent in-vitro fertilization/intracytoplasmic sperm injection over 3 years was studied after dividing into three groups: Group A (96)-normal AFC (≥10), direct oocyte retrieval at 120 mmHg, Group B (41)-low AFC (<10), direct retrieval at 140-mmHg, Group C (35)-low AFC, follicular flushing, and aspiration at 120-mmHg. In each group, oocyte yield, embryo quality, and pregnancy out comes were assessed. Results: The oocyte and embryo yield in Groups A and B were comparable (P > 0.05) but were significantly less in Group C (P < 0.05). The pregnancy rates in Groups A and B were similar (35.4%, 39%) but were significantly less (17.1%) in Group C (P < 0.05). The live birth rate was 76% in Group A, 69% in Group B, and 50% in Group C. The miscarriage rates in the three groups were 21%, 31%, and 50%, respectively. Conclusion: Direct oocyte retrieval with 140-mmHg showed significantly better oocyte yield and pregnancy outcomes compared to flushing and aspiration in women with low AFC.

AB - Oocyte retrieval in women with low ovarian reserve is challenging and often results in poor pregnancy outcomes. Aim: The aim was to compare outcomes of oocyte retrieval using three aspiration methods in women with normal and low antral follicle counts (AFCs). Study Design: Retrospective cohort study. Setting: Tertiary care hospital. Materials and Methods: Data from 172 women who underwent in-vitro fertilization/intracytoplasmic sperm injection over 3 years was studied after dividing into three groups: Group A (96)-normal AFC (≥10), direct oocyte retrieval at 120 mmHg, Group B (41)-low AFC (<10), direct retrieval at 140-mmHg, Group C (35)-low AFC, follicular flushing, and aspiration at 120-mmHg. In each group, oocyte yield, embryo quality, and pregnancy out comes were assessed. Results: The oocyte and embryo yield in Groups A and B were comparable (P > 0.05) but were significantly less in Group C (P < 0.05). The pregnancy rates in Groups A and B were similar (35.4%, 39%) but were significantly less (17.1%) in Group C (P < 0.05). The live birth rate was 76% in Group A, 69% in Group B, and 50% in Group C. The miscarriage rates in the three groups were 21%, 31%, and 50%, respectively. Conclusion: Direct oocyte retrieval with 140-mmHg showed significantly better oocyte yield and pregnancy outcomes compared to flushing and aspiration in women with low AFC.

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