Opportunistic infections among People Living with HIV (PLHIV) with Diabetes Mellitus (DM) attending a tertiary care hospital in coastal city of South India

Poojary Indira, Papanna Mohan Kumar, Shenoy Shalini, Kulkarni Vaman

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: HIV/AIDS and Diabetes Mellitus are the diseases' known to supress cell mediated immunity and predispose patients for opportunistic infections. Hence, we conducted a study to compare the common opportunistic infections (OIs) between People Living with HIV with DM (PLHIV-DM) and PLHIV without DM (PLHIV). Methodology: PLHIV with DM and without DM (1:1) were prospectively included in the study from January 2011 to January 2012 at a tertiary care hospital in Mangalore city. Patients were classified as Diabetic if their fasting plasma glucose was ≥ 7.0mmol/l (126mg/dl) or 2-h plasma glucose was ≥11.1mmol/l (200mg/dl). Standard procedures and techniques were followed for diagnosis of OIs as per WHO guidelines. The data was entered and analyzed using Statistical Package for Social Sciences (SPSS) version 11.5. Findings: The study included 37 PLHIV with DM and 37 PLHIV without DM and both groups were treated with Anti-Retroviral Therapy (ART). Themedian age was 47 years (IQR: 41-55years) for PLHIV-DM as compared to 40 years (IQR: 35-45.5 years) for PLHIV (p<0.0001). PLHIVDM had median CD4 counts of 245 (IQR: 148-348) cells/μl compared to 150(IQR: 70-278) cells/μl for PLHIV (p = 0.02). Common OIs included oral candidiasis (49%of PLHIV-DM and 35%of PLHIV); Cryptococcal meningitis (19%of PLHIV-DMand 16%of PLHIV); Pneumocystis jiroveci pneumonia (5%of PLHIV-DM and 18%of PLHIV); extra pulmonary tuberculosis (22%of PLHIV-DM and 34.5%of PLHIV); and Cerebral toxoplasmosis (11%of PLHIV-DM and 13.5% of PLHIV). Microbiological testing of samples from PLHIV- DM,C krusei was the most common Candida species isolated from 9 out of 18 samples. Out of six pulmonary TB samples cultured, four grew Non-tuberculosis mycobacteria (NTM) and twoMycobacterium tuberculosis complexes. Conclusions: Study did not identify any significant difference in profile of opportunistic infections (OIs) between PLHIV with and without Diabetes.

Original languageEnglish
Article numbere0136280
JournalPLoS One
Volume10
Issue number8
DOIs
Publication statusPublished - 19-08-2015
Externally publishedYes

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Opportunistic Infections
Tertiary Healthcare
Medical problems
diabetes mellitus
Tertiary Care Centers
India
Diabetes Mellitus
HIV
infection
Plasmas
tuberculosis
Glucose
Social sciences
Candida
lungs
Cerebral Toxoplasmosis
Cryptococcal Meningitis
Oral Candidiasis
Pneumocystis carinii
glucose

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

@article{5a688f24fc884797b5fecfe8eb0ea11e,
title = "Opportunistic infections among People Living with HIV (PLHIV) with Diabetes Mellitus (DM) attending a tertiary care hospital in coastal city of South India",
abstract = "Background: HIV/AIDS and Diabetes Mellitus are the diseases' known to supress cell mediated immunity and predispose patients for opportunistic infections. Hence, we conducted a study to compare the common opportunistic infections (OIs) between People Living with HIV with DM (PLHIV-DM) and PLHIV without DM (PLHIV). Methodology: PLHIV with DM and without DM (1:1) were prospectively included in the study from January 2011 to January 2012 at a tertiary care hospital in Mangalore city. Patients were classified as Diabetic if their fasting plasma glucose was ≥ 7.0mmol/l (126mg/dl) or 2-h plasma glucose was ≥11.1mmol/l (200mg/dl). Standard procedures and techniques were followed for diagnosis of OIs as per WHO guidelines. The data was entered and analyzed using Statistical Package for Social Sciences (SPSS) version 11.5. Findings: The study included 37 PLHIV with DM and 37 PLHIV without DM and both groups were treated with Anti-Retroviral Therapy (ART). Themedian age was 47 years (IQR: 41-55years) for PLHIV-DM as compared to 40 years (IQR: 35-45.5 years) for PLHIV (p<0.0001). PLHIVDM had median CD4 counts of 245 (IQR: 148-348) cells/μl compared to 150(IQR: 70-278) cells/μl for PLHIV (p = 0.02). Common OIs included oral candidiasis (49{\%}of PLHIV-DM and 35{\%}of PLHIV); Cryptococcal meningitis (19{\%}of PLHIV-DMand 16{\%}of PLHIV); Pneumocystis jiroveci pneumonia (5{\%}of PLHIV-DM and 18{\%}of PLHIV); extra pulmonary tuberculosis (22{\%}of PLHIV-DM and 34.5{\%}of PLHIV); and Cerebral toxoplasmosis (11{\%}of PLHIV-DM and 13.5{\%} of PLHIV). Microbiological testing of samples from PLHIV- DM,C krusei was the most common Candida species isolated from 9 out of 18 samples. Out of six pulmonary TB samples cultured, four grew Non-tuberculosis mycobacteria (NTM) and twoMycobacterium tuberculosis complexes. Conclusions: Study did not identify any significant difference in profile of opportunistic infections (OIs) between PLHIV with and without Diabetes.",
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Opportunistic infections among People Living with HIV (PLHIV) with Diabetes Mellitus (DM) attending a tertiary care hospital in coastal city of South India. / Indira, Poojary; Kumar, Papanna Mohan; Shalini, Shenoy; Vaman, Kulkarni.

In: PLoS One, Vol. 10, No. 8, e0136280, 19.08.2015.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Opportunistic infections among People Living with HIV (PLHIV) with Diabetes Mellitus (DM) attending a tertiary care hospital in coastal city of South India

AU - Indira, Poojary

AU - Kumar, Papanna Mohan

AU - Shalini, Shenoy

AU - Vaman, Kulkarni

PY - 2015/8/19

Y1 - 2015/8/19

N2 - Background: HIV/AIDS and Diabetes Mellitus are the diseases' known to supress cell mediated immunity and predispose patients for opportunistic infections. Hence, we conducted a study to compare the common opportunistic infections (OIs) between People Living with HIV with DM (PLHIV-DM) and PLHIV without DM (PLHIV). Methodology: PLHIV with DM and without DM (1:1) were prospectively included in the study from January 2011 to January 2012 at a tertiary care hospital in Mangalore city. Patients were classified as Diabetic if their fasting plasma glucose was ≥ 7.0mmol/l (126mg/dl) or 2-h plasma glucose was ≥11.1mmol/l (200mg/dl). Standard procedures and techniques were followed for diagnosis of OIs as per WHO guidelines. The data was entered and analyzed using Statistical Package for Social Sciences (SPSS) version 11.5. Findings: The study included 37 PLHIV with DM and 37 PLHIV without DM and both groups were treated with Anti-Retroviral Therapy (ART). Themedian age was 47 years (IQR: 41-55years) for PLHIV-DM as compared to 40 years (IQR: 35-45.5 years) for PLHIV (p<0.0001). PLHIVDM had median CD4 counts of 245 (IQR: 148-348) cells/μl compared to 150(IQR: 70-278) cells/μl for PLHIV (p = 0.02). Common OIs included oral candidiasis (49%of PLHIV-DM and 35%of PLHIV); Cryptococcal meningitis (19%of PLHIV-DMand 16%of PLHIV); Pneumocystis jiroveci pneumonia (5%of PLHIV-DM and 18%of PLHIV); extra pulmonary tuberculosis (22%of PLHIV-DM and 34.5%of PLHIV); and Cerebral toxoplasmosis (11%of PLHIV-DM and 13.5% of PLHIV). Microbiological testing of samples from PLHIV- DM,C krusei was the most common Candida species isolated from 9 out of 18 samples. Out of six pulmonary TB samples cultured, four grew Non-tuberculosis mycobacteria (NTM) and twoMycobacterium tuberculosis complexes. Conclusions: Study did not identify any significant difference in profile of opportunistic infections (OIs) between PLHIV with and without Diabetes.

AB - Background: HIV/AIDS and Diabetes Mellitus are the diseases' known to supress cell mediated immunity and predispose patients for opportunistic infections. Hence, we conducted a study to compare the common opportunistic infections (OIs) between People Living with HIV with DM (PLHIV-DM) and PLHIV without DM (PLHIV). Methodology: PLHIV with DM and without DM (1:1) were prospectively included in the study from January 2011 to January 2012 at a tertiary care hospital in Mangalore city. Patients were classified as Diabetic if their fasting plasma glucose was ≥ 7.0mmol/l (126mg/dl) or 2-h plasma glucose was ≥11.1mmol/l (200mg/dl). Standard procedures and techniques were followed for diagnosis of OIs as per WHO guidelines. The data was entered and analyzed using Statistical Package for Social Sciences (SPSS) version 11.5. Findings: The study included 37 PLHIV with DM and 37 PLHIV without DM and both groups were treated with Anti-Retroviral Therapy (ART). Themedian age was 47 years (IQR: 41-55years) for PLHIV-DM as compared to 40 years (IQR: 35-45.5 years) for PLHIV (p<0.0001). PLHIVDM had median CD4 counts of 245 (IQR: 148-348) cells/μl compared to 150(IQR: 70-278) cells/μl for PLHIV (p = 0.02). Common OIs included oral candidiasis (49%of PLHIV-DM and 35%of PLHIV); Cryptococcal meningitis (19%of PLHIV-DMand 16%of PLHIV); Pneumocystis jiroveci pneumonia (5%of PLHIV-DM and 18%of PLHIV); extra pulmonary tuberculosis (22%of PLHIV-DM and 34.5%of PLHIV); and Cerebral toxoplasmosis (11%of PLHIV-DM and 13.5% of PLHIV). Microbiological testing of samples from PLHIV- DM,C krusei was the most common Candida species isolated from 9 out of 18 samples. Out of six pulmonary TB samples cultured, four grew Non-tuberculosis mycobacteria (NTM) and twoMycobacterium tuberculosis complexes. Conclusions: Study did not identify any significant difference in profile of opportunistic infections (OIs) between PLHIV with and without Diabetes.

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