Optic neuritis

Experience from a south Indian demyelinating disease registry

Lekha Pandit, Rajesh Shetty, Zulkifli Misri, Subrahmanya Bhat, Hrishikesh Amin, Vijay Pai, Rammohan Rao

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Natural history of optic neuritis (OPN) has not been studied in India. Aim: To study consecutive patients with optic neuritis as the initial manifestation of the neurologic disease and with disease duration of 3 or more years registered in the Mangalore Demyelinating Disease Registry. Materials and Methods: The study included 59 patients with a primary diagnosis of optic neuritis (confirmed by either an ophthalmologist or a neurologist or both). All the patients were investigated and followed-up in the clinic. Results: During the follow-up of the 59 patients, 29 (49%) patients developed multiple sclerosis (MS); 3 (5%) patients neuromyelitis optica (NMO); and 13 (22%) patients chronic relapsing inflammatory optic neuritis (CRION), while the remaining 14 (24%) did not either progress or relapse, monophasic OPN. An initial abnormal magnetic resonance imaging predicted conversion to MS in all 7 patients who had imaging at onset. Patients with NMO were left with significant residual visual loss distinguishing NMO from MS. In this large series of patients with CRION, nearly 50% of patients had deterioration in vision while steroids were being tapered. Long-term immunosuppression was essential for maintaining good visual outcome in both NMO and CRION. Conclusions: Optic neuritis in India appears similar to that in the West with nearly 50% developing MS in the long term.

Original languageEnglish
Pages (from-to)470-475
Number of pages6
JournalNeurology India
Volume60
Issue number5
DOIs
Publication statusPublished - 01-09-2012

Fingerprint

Optic Neuritis
Demyelinating Diseases
Registries
Neuromyelitis Optica
Multiple Sclerosis
India
Nervous System Diseases
Immunosuppression
Steroids
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Pandit, Lekha ; Shetty, Rajesh ; Misri, Zulkifli ; Bhat, Subrahmanya ; Amin, Hrishikesh ; Pai, Vijay ; Rao, Rammohan. / Optic neuritis : Experience from a south Indian demyelinating disease registry. In: Neurology India. 2012 ; Vol. 60, No. 5. pp. 470-475.
@article{953eeabd4de34e9f92ee94fd968bc969,
title = "Optic neuritis: Experience from a south Indian demyelinating disease registry",
abstract = "Background: Natural history of optic neuritis (OPN) has not been studied in India. Aim: To study consecutive patients with optic neuritis as the initial manifestation of the neurologic disease and with disease duration of 3 or more years registered in the Mangalore Demyelinating Disease Registry. Materials and Methods: The study included 59 patients with a primary diagnosis of optic neuritis (confirmed by either an ophthalmologist or a neurologist or both). All the patients were investigated and followed-up in the clinic. Results: During the follow-up of the 59 patients, 29 (49{\%}) patients developed multiple sclerosis (MS); 3 (5{\%}) patients neuromyelitis optica (NMO); and 13 (22{\%}) patients chronic relapsing inflammatory optic neuritis (CRION), while the remaining 14 (24{\%}) did not either progress or relapse, monophasic OPN. An initial abnormal magnetic resonance imaging predicted conversion to MS in all 7 patients who had imaging at onset. Patients with NMO were left with significant residual visual loss distinguishing NMO from MS. In this large series of patients with CRION, nearly 50{\%} of patients had deterioration in vision while steroids were being tapered. Long-term immunosuppression was essential for maintaining good visual outcome in both NMO and CRION. Conclusions: Optic neuritis in India appears similar to that in the West with nearly 50{\%} developing MS in the long term.",
author = "Lekha Pandit and Rajesh Shetty and Zulkifli Misri and Subrahmanya Bhat and Hrishikesh Amin and Vijay Pai and Rammohan Rao",
year = "2012",
month = "9",
day = "1",
doi = "10.4103/0028-3886.103186",
language = "English",
volume = "60",
pages = "470--475",
journal = "Neurology India",
issn = "0028-3886",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "5",

}

Pandit, L, Shetty, R, Misri, Z, Bhat, S, Amin, H, Pai, V & Rao, R 2012, 'Optic neuritis: Experience from a south Indian demyelinating disease registry', Neurology India, vol. 60, no. 5, pp. 470-475. https://doi.org/10.4103/0028-3886.103186

Optic neuritis : Experience from a south Indian demyelinating disease registry. / Pandit, Lekha; Shetty, Rajesh; Misri, Zulkifli; Bhat, Subrahmanya; Amin, Hrishikesh; Pai, Vijay; Rao, Rammohan.

In: Neurology India, Vol. 60, No. 5, 01.09.2012, p. 470-475.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Optic neuritis

T2 - Experience from a south Indian demyelinating disease registry

AU - Pandit, Lekha

AU - Shetty, Rajesh

AU - Misri, Zulkifli

AU - Bhat, Subrahmanya

AU - Amin, Hrishikesh

AU - Pai, Vijay

AU - Rao, Rammohan

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Background: Natural history of optic neuritis (OPN) has not been studied in India. Aim: To study consecutive patients with optic neuritis as the initial manifestation of the neurologic disease and with disease duration of 3 or more years registered in the Mangalore Demyelinating Disease Registry. Materials and Methods: The study included 59 patients with a primary diagnosis of optic neuritis (confirmed by either an ophthalmologist or a neurologist or both). All the patients were investigated and followed-up in the clinic. Results: During the follow-up of the 59 patients, 29 (49%) patients developed multiple sclerosis (MS); 3 (5%) patients neuromyelitis optica (NMO); and 13 (22%) patients chronic relapsing inflammatory optic neuritis (CRION), while the remaining 14 (24%) did not either progress or relapse, monophasic OPN. An initial abnormal magnetic resonance imaging predicted conversion to MS in all 7 patients who had imaging at onset. Patients with NMO were left with significant residual visual loss distinguishing NMO from MS. In this large series of patients with CRION, nearly 50% of patients had deterioration in vision while steroids were being tapered. Long-term immunosuppression was essential for maintaining good visual outcome in both NMO and CRION. Conclusions: Optic neuritis in India appears similar to that in the West with nearly 50% developing MS in the long term.

AB - Background: Natural history of optic neuritis (OPN) has not been studied in India. Aim: To study consecutive patients with optic neuritis as the initial manifestation of the neurologic disease and with disease duration of 3 or more years registered in the Mangalore Demyelinating Disease Registry. Materials and Methods: The study included 59 patients with a primary diagnosis of optic neuritis (confirmed by either an ophthalmologist or a neurologist or both). All the patients were investigated and followed-up in the clinic. Results: During the follow-up of the 59 patients, 29 (49%) patients developed multiple sclerosis (MS); 3 (5%) patients neuromyelitis optica (NMO); and 13 (22%) patients chronic relapsing inflammatory optic neuritis (CRION), while the remaining 14 (24%) did not either progress or relapse, monophasic OPN. An initial abnormal magnetic resonance imaging predicted conversion to MS in all 7 patients who had imaging at onset. Patients with NMO were left with significant residual visual loss distinguishing NMO from MS. In this large series of patients with CRION, nearly 50% of patients had deterioration in vision while steroids were being tapered. Long-term immunosuppression was essential for maintaining good visual outcome in both NMO and CRION. Conclusions: Optic neuritis in India appears similar to that in the West with nearly 50% developing MS in the long term.

UR - http://www.scopus.com/inward/record.url?scp=84870008942&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870008942&partnerID=8YFLogxK

U2 - 10.4103/0028-3886.103186

DO - 10.4103/0028-3886.103186

M3 - Article

VL - 60

SP - 470

EP - 475

JO - Neurology India

JF - Neurology India

SN - 0028-3886

IS - 5

ER -