Optimisation of carbon nanotubes for advanced diagnosis and biomedical application

Khalid Parwez, Suman Veerappa Budihal

Research output: Contribution to journalArticle

Abstract

Nanomaterials have a broad spectrum of applications in biomedical fields. The carbon nanotubes (CNTs) are among the most versatile and well-characterised members of this group of materials. This review aims to discuss how to utilise CNTs as a diagnostic tool. Functionalisation with antibodies has gained significance in recent years among the various way of functionalisation of CNTs. Antibodies make their surface sensitive to surroundings for immuno-sensing. Surface passivation with other proteins is required to inhibit the non-specific binding of biomolecules on the hydrophobic carbon nanotube surface for ultrasensitive detection of biological species. CNT-based immuno-sensors provide excellent results with a promising sensitivity and reproducibility and, in combination with novel devices [such as a microfluidic electrochemical biosensor, nanoelectromechanical systems (NEMS), paper-based analytical devices (PADs), field effect transistors (FET)]. This combination offers an attractive analytical approach for the fast, low-cost, and accessible detection of trace prognostic biomarkers, microbial pathogens, environmental pollutants, and toxins.

Original languageEnglish
Pages (from-to)217-238
Number of pages22
JournalInternational Journal of Nanoparticles
Volume11
Issue number3
DOIs
Publication statusPublished - 01-01-2019
Externally publishedYes

Fingerprint

Carbon Nanotubes
Carbon nanotubes
carbon nanotubes
optimization
antibodies
Antibodies
NEMS
Environmental Pollutants
pathogens
biomarkers
Biomolecules
Biomarkers
Pathogens
Field effect transistors
bioinstrumentation
Nanostructured materials
Microfluidics
Passivation
Biosensors
passivity

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

Cite this

Parwez, Khalid ; Budihal, Suman Veerappa. / Optimisation of carbon nanotubes for advanced diagnosis and biomedical application. In: International Journal of Nanoparticles. 2019 ; Vol. 11, No. 3. pp. 217-238.
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Optimisation of carbon nanotubes for advanced diagnosis and biomedical application. / Parwez, Khalid; Budihal, Suman Veerappa.

In: International Journal of Nanoparticles, Vol. 11, No. 3, 01.01.2019, p. 217-238.

Research output: Contribution to journalArticle

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