Optimization of delivery of betamethasone-dipropionate from skin preparation

M. Bhat, S. D. Shenoy, N. Udupa, C. R. Srinivas

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Abstract

The permeation studies have been conducted for betamethasone dipropionate from ointment formulation. The permeation was optimized using several permeation enhancers such as surfactants, B-cyclodextrin, bile salt, iontophoresis, sonophoresis, and hyperthermia. The permeation is increased with the iontophoresis and sonophoresis. The permeation enhancers used also increased the permeation through sigma membrane as well as through rat abdominal skin. By selecting suitable physical method of enhancement and chemical penetration enhancers, the activity of the drug can be optimized.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalIndian Drugs
Volume32
Issue number5
Publication statusPublished - 1995

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All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmaceutical Science

Cite this

Bhat, M., Shenoy, S. D., Udupa, N., & Srinivas, C. R. (1995). Optimization of delivery of betamethasone-dipropionate from skin preparation. Indian Drugs, 32(5), 211-214.