Optimizing fast dissolving dosage form of diclofenac sodium by rapidly disintegrating agents

V. Shenoy, S. Agrawal, S. Pandey

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Fast dissolving tablets of diclofenac sodium were prepared using direct compression after incorporating superdisintegrants such as cross linked carboxymethylcellulose, sodium starch glycolate and cross linked povidone in different concentrations. All the formulations were evaluated for the influence of disintegrants and their concentrations on the characteristics of fast dissolving tablet mainly in terms of disintegration time and dissolution rate. Tablets containing cross-linked carboxymethylcellulose showed better disintegrating character along with rapid release (90% drug release in 10 min.). No appreciable difference was found between the formulations containing other two superdisintegrants. The concentration of the superdisintegrants had also an effect on disintegration time and in vitro dissolution. There seems to be a trend towards use of higher level of disintegrants producing rapid disintegration and faster dissolution. The resulting tablets were also evaluated for its hardness and friability and were found to be independent of disintegrant concentration.
Original languageEnglish
Pages (from-to)197-201
Number of pages5
JournalIndian Journal of Pharmaceutical Sciences
Volume65
Issue number2
Publication statusPublished - 2003

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Diclofenac
Dosage Forms
Tablets
Carboxymethylcellulose Sodium
Povidone
Hardness

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abstract = "Fast dissolving tablets of diclofenac sodium were prepared using direct compression after incorporating superdisintegrants such as cross linked carboxymethylcellulose, sodium starch glycolate and cross linked povidone in different concentrations. All the formulations were evaluated for the influence of disintegrants and their concentrations on the characteristics of fast dissolving tablet mainly in terms of disintegration time and dissolution rate. Tablets containing cross-linked carboxymethylcellulose showed better disintegrating character along with rapid release (90{\%} drug release in 10 min.). No appreciable difference was found between the formulations containing other two superdisintegrants. The concentration of the superdisintegrants had also an effect on disintegration time and in vitro dissolution. There seems to be a trend towards use of higher level of disintegrants producing rapid disintegration and faster dissolution. The resulting tablets were also evaluated for its hardness and friability and were found to be independent of disintegrant concentration.",
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note = "Cited By :29 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Pandey, S.; Department of Pharmaceutics, College of Pharmaceutical Sciences, MAHE, Manipal-576 119, India; email: s.pandey@cops.manipal.edu References: Habib, W., Khankari, R., Hontz, J., (2000) Crit. Rev. Ther. Drug Carr. Syst, 17, p. 61; Masaki, K., (1995), US Patent No. 5,466,464; Remon, J.P., Corveleyn, S., (2000), US Patent No. US6,010,719; Seager, H., (1998) J. Pharm. Pharmacol, 50, p. 375; Allen, L.V., Wang, B., (1997), US Patent No. US5,635,210; Allen, L.V., Wang, B., Davies, J.D., (1997), US Patent No. US5, 635,210; Ito, A., Sugihara, M., (1996) Chem. Pharm. Bull, 44, p. 2132; Visavarungroj, N., Remon, J.P., (1990) Int. J. Pharm, 62, p. 125; Chang, R., Guo, X., Burnside, B.A., (2000) Pharm.Technol, 24, p. 52; Shangraw, R.F., Mitrevej, A., Shah, M.A., (1980) Pharm.Technol, 4, p. 49; Kuchekar, B.S., Bhise, S.B., Armugam, V., (2001) Indian J. Pharm. Edu, 35, p. 150; Gordon, M.S., Chatterjee, B., Chowhan, Z.T., (1990) J. Pharm. Sci, 79, p. 43; Munoz-Ruitz, A., Gallego, R., Del pozo, M., Jimenez-Castellanos, M.R., (1994) Eur. J. Pharm. and Biopharm, 40, p. 36; Indian Pharmacopoeia, Ministry of health and family welfare, Govt. of India, Delhi, 1996, 736; (1987) The Theory and Practice of Industrial Pharmacy, p. 293. , Lachmann, L, Liberman, H.A. and Kanig, J.L. Eds, 3rd Edn, Varghese Publishing House, Mumbai; Shangraw, R.F., Mitrevej, A., Shah, M., (1980) Pharm. Technol, 4, p. 49; Ganderton, D., Fraser, D.R., (1970) J. Pharm. Pharmacol, 22, pp. 95S",
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Optimizing fast dissolving dosage form of diclofenac sodium by rapidly disintegrating agents. / Shenoy, V.; Agrawal, S.; Pandey, S.

In: Indian Journal of Pharmaceutical Sciences, Vol. 65, No. 2, 2003, p. 197-201.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Optimizing fast dissolving dosage form of diclofenac sodium by rapidly disintegrating agents

AU - Shenoy, V.

AU - Agrawal, S.

AU - Pandey, S.

N1 - Cited By :29 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Pandey, S.; Department of Pharmaceutics, College of Pharmaceutical Sciences, MAHE, Manipal-576 119, India; email: s.pandey@cops.manipal.edu References: Habib, W., Khankari, R., Hontz, J., (2000) Crit. Rev. Ther. Drug Carr. Syst, 17, p. 61; Masaki, K., (1995), US Patent No. 5,466,464; Remon, J.P., Corveleyn, S., (2000), US Patent No. US6,010,719; Seager, H., (1998) J. Pharm. Pharmacol, 50, p. 375; Allen, L.V., Wang, B., (1997), US Patent No. US5,635,210; Allen, L.V., Wang, B., Davies, J.D., (1997), US Patent No. US5, 635,210; Ito, A., Sugihara, M., (1996) Chem. Pharm. Bull, 44, p. 2132; Visavarungroj, N., Remon, J.P., (1990) Int. J. Pharm, 62, p. 125; Chang, R., Guo, X., Burnside, B.A., (2000) Pharm.Technol, 24, p. 52; Shangraw, R.F., Mitrevej, A., Shah, M.A., (1980) Pharm.Technol, 4, p. 49; Kuchekar, B.S., Bhise, S.B., Armugam, V., (2001) Indian J. Pharm. Edu, 35, p. 150; Gordon, M.S., Chatterjee, B., Chowhan, Z.T., (1990) J. Pharm. Sci, 79, p. 43; Munoz-Ruitz, A., Gallego, R., Del pozo, M., Jimenez-Castellanos, M.R., (1994) Eur. J. Pharm. and Biopharm, 40, p. 36; Indian Pharmacopoeia, Ministry of health and family welfare, Govt. of India, Delhi, 1996, 736; (1987) The Theory and Practice of Industrial Pharmacy, p. 293. , Lachmann, L, Liberman, H.A. and Kanig, J.L. Eds, 3rd Edn, Varghese Publishing House, Mumbai; Shangraw, R.F., Mitrevej, A., Shah, M., (1980) Pharm. Technol, 4, p. 49; Ganderton, D., Fraser, D.R., (1970) J. Pharm. Pharmacol, 22, pp. 95S

PY - 2003

Y1 - 2003

N2 - Fast dissolving tablets of diclofenac sodium were prepared using direct compression after incorporating superdisintegrants such as cross linked carboxymethylcellulose, sodium starch glycolate and cross linked povidone in different concentrations. All the formulations were evaluated for the influence of disintegrants and their concentrations on the characteristics of fast dissolving tablet mainly in terms of disintegration time and dissolution rate. Tablets containing cross-linked carboxymethylcellulose showed better disintegrating character along with rapid release (90% drug release in 10 min.). No appreciable difference was found between the formulations containing other two superdisintegrants. The concentration of the superdisintegrants had also an effect on disintegration time and in vitro dissolution. There seems to be a trend towards use of higher level of disintegrants producing rapid disintegration and faster dissolution. The resulting tablets were also evaluated for its hardness and friability and were found to be independent of disintegrant concentration.

AB - Fast dissolving tablets of diclofenac sodium were prepared using direct compression after incorporating superdisintegrants such as cross linked carboxymethylcellulose, sodium starch glycolate and cross linked povidone in different concentrations. All the formulations were evaluated for the influence of disintegrants and their concentrations on the characteristics of fast dissolving tablet mainly in terms of disintegration time and dissolution rate. Tablets containing cross-linked carboxymethylcellulose showed better disintegrating character along with rapid release (90% drug release in 10 min.). No appreciable difference was found between the formulations containing other two superdisintegrants. The concentration of the superdisintegrants had also an effect on disintegration time and in vitro dissolution. There seems to be a trend towards use of higher level of disintegrants producing rapid disintegration and faster dissolution. The resulting tablets were also evaluated for its hardness and friability and were found to be independent of disintegrant concentration.

M3 - Article

VL - 65

SP - 197

EP - 201

JO - Indian Journal of Pharmaceutical Sciences

JF - Indian Journal of Pharmaceutical Sciences

SN - 0250-474X

IS - 2

ER -