Oral candidal carriage correlates with CD4+ cell count but not with HIV and highly active antiretroviral therapy status

Parul Sah, Pratik Patel, Chetana Chandrashekar, Suganthi Martena, Mamatha Ballal, Manjayya Hegde, Vasudeva Guddattu, Craig Murdoch, Mohit Sharma, Raghu Radhakrishnan

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


AIM: The occurrence of oropharyngeal candidiasis (OPC) may be influenced by oral candidal carriage (OCC). Although OPC is strongly associated with low CD4+ cell count (400-700 cells/mm3 ) and a lack of highly active antiretroviral therapy (HAART), the effect of these two parameters on OCC is debatable. We investigated the oral candidal carriage, species diversity, antifungal susceptibility and the association of OCC with CD4+ cell count and HAART. METHODS: Oral candidal isolates from 120 HIV+ patients (60 receiving and 60 not receiving HAART) and 60 healthy controls were quantified, and their species determined using standard culture and biochemical methods, followed by antifungal susceptibility testing using the agar dilution method. RESULTS: The OCC was significantly higher in HIV+ patients; Candida albicans was the most frequently isolated species in both groups, followed by Candida tropicalis. Candidal density carriage correlated significantly with CD4+ cell count, but not with HIV and HAART status. Among the isolates from HIV+ patients, 35.4% showed reduced susceptibility to fluconazole. CONCLUSION: HIV status results in significantly elevated rates of OCC C albicans remains the predominant pathogen, although other species are emerging rapidly. Resistance to fluconazole is on the rise, and more efficient treatment strategies need to be implemented.

Original languageEnglish
Pages (from-to)e12438
JournalJournal of investigative and clinical dentistry
Issue number4
Publication statusPublished - 01-11-2019

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Fingerprint Dive into the research topics of 'Oral candidal carriage correlates with CD4<sup>+</sup> cell count but not with HIV and highly active antiretroviral therapy status'. Together they form a unique fingerprint.

Cite this