Abstract

Background: Breast cancer is one of the most common cancers in India. Most of the patients with breast cancer are treated with chemotherapy which has multiple oral complications. Aims: The objectives of this study were to describe the occurrence of taste disturbances, xerostomia, oral mucositis, oral pigmentation, and candidal and salivary changes among patients receiving chemotherapy for breast cancer. Methods: Fifty-two women with newly diagnosed breast cancer (without distant metastasis), eligible for adjuvant/neoadjuvant chemotherapy (cyclophosphamide and adriamycin, 4 cycles × 3 weeks), were included in this study. All the observations were noted before, during (after 6 weeks of starting chemotherapy), and after the completion of chemotherapy (after 12 weeks of starting chemotherapy). Statistical Analysis Used: Variables such as mucositis, salivary flow rate, salivary pH, and candidal carriage rate were compared at baseline, and at 1st and 2nd follow-ups using Wilcoxon signed-rank test (P value corrected for α for pair-wise comparisons). Results: Mean unstimulated whole salivary flow rate reduced from 0.5 ml/min to 0.3 ml/min, and the mean colony-forming units of Candida reduced from 32.3 × 103 cells/ml to 13.1 × 103 cells/ml at the end of the study period. Xerostomia, taste disturbances, and oral mucosal pigmentation increased from 28.8% to 50%. Conclusions: There was a discernible change in oral mucosal, salivary, and candidal status during the course of the study.

Original languageEnglish
Pages (from-to)261-268
Number of pages8
JournalIndian Journal of Dental Research
Volume28
Issue number3
DOIs
Publication statusPublished - 01-05-2017

Fingerprint

Breast Neoplasms
Drug Therapy
Xerostomia
Pigmentation
Stomatitis
Mucositis
Adjuvant Chemotherapy
Nonparametric Statistics
Candida
Doxorubicin
Cyclophosphamide
India
Stem Cells
Neoplasm Metastasis
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Dentistry(all)

Cite this

@article{970ea995d51f47418c57f5758eee56d4,
title = "Oral changes in patients undergoing chemotherapy for breast cancer",
abstract = "Background: Breast cancer is one of the most common cancers in India. Most of the patients with breast cancer are treated with chemotherapy which has multiple oral complications. Aims: The objectives of this study were to describe the occurrence of taste disturbances, xerostomia, oral mucositis, oral pigmentation, and candidal and salivary changes among patients receiving chemotherapy for breast cancer. Methods: Fifty-two women with newly diagnosed breast cancer (without distant metastasis), eligible for adjuvant/neoadjuvant chemotherapy (cyclophosphamide and adriamycin, 4 cycles × 3 weeks), were included in this study. All the observations were noted before, during (after 6 weeks of starting chemotherapy), and after the completion of chemotherapy (after 12 weeks of starting chemotherapy). Statistical Analysis Used: Variables such as mucositis, salivary flow rate, salivary pH, and candidal carriage rate were compared at baseline, and at 1st and 2nd follow-ups using Wilcoxon signed-rank test (P value corrected for α for pair-wise comparisons). Results: Mean unstimulated whole salivary flow rate reduced from 0.5 ml/min to 0.3 ml/min, and the mean colony-forming units of Candida reduced from 32.3 × 103 cells/ml to 13.1 × 103 cells/ml at the end of the study period. Xerostomia, taste disturbances, and oral mucosal pigmentation increased from 28.8{\%} to 50{\%}. Conclusions: There was a discernible change in oral mucosal, salivary, and candidal status during the course of the study.",
author = "Shruthi Acharya and Pai, {Keerthilatha Murlidhar} and Sujatha Bhat and Ballal Mamatha and Bejadi, {Vadhiraj M.} and Shashidhar Acharya",
year = "2017",
month = "5",
day = "1",
doi = "10.4103/ijdr.IJDR-379-16",
language = "English",
volume = "28",
pages = "261--268",
journal = "Indian Journal of Dental Research",
issn = "0970-9290",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "3",

}

Oral changes in patients undergoing chemotherapy for breast cancer. / Acharya, Shruthi; Pai, Keerthilatha Murlidhar; Bhat, Sujatha; Mamatha, Ballal; Bejadi, Vadhiraj M.; Acharya, Shashidhar.

In: Indian Journal of Dental Research, Vol. 28, No. 3, 01.05.2017, p. 261-268.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Oral changes in patients undergoing chemotherapy for breast cancer

AU - Acharya, Shruthi

AU - Pai, Keerthilatha Murlidhar

AU - Bhat, Sujatha

AU - Mamatha, Ballal

AU - Bejadi, Vadhiraj M.

AU - Acharya, Shashidhar

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Background: Breast cancer is one of the most common cancers in India. Most of the patients with breast cancer are treated with chemotherapy which has multiple oral complications. Aims: The objectives of this study were to describe the occurrence of taste disturbances, xerostomia, oral mucositis, oral pigmentation, and candidal and salivary changes among patients receiving chemotherapy for breast cancer. Methods: Fifty-two women with newly diagnosed breast cancer (without distant metastasis), eligible for adjuvant/neoadjuvant chemotherapy (cyclophosphamide and adriamycin, 4 cycles × 3 weeks), were included in this study. All the observations were noted before, during (after 6 weeks of starting chemotherapy), and after the completion of chemotherapy (after 12 weeks of starting chemotherapy). Statistical Analysis Used: Variables such as mucositis, salivary flow rate, salivary pH, and candidal carriage rate were compared at baseline, and at 1st and 2nd follow-ups using Wilcoxon signed-rank test (P value corrected for α for pair-wise comparisons). Results: Mean unstimulated whole salivary flow rate reduced from 0.5 ml/min to 0.3 ml/min, and the mean colony-forming units of Candida reduced from 32.3 × 103 cells/ml to 13.1 × 103 cells/ml at the end of the study period. Xerostomia, taste disturbances, and oral mucosal pigmentation increased from 28.8% to 50%. Conclusions: There was a discernible change in oral mucosal, salivary, and candidal status during the course of the study.

AB - Background: Breast cancer is one of the most common cancers in India. Most of the patients with breast cancer are treated with chemotherapy which has multiple oral complications. Aims: The objectives of this study were to describe the occurrence of taste disturbances, xerostomia, oral mucositis, oral pigmentation, and candidal and salivary changes among patients receiving chemotherapy for breast cancer. Methods: Fifty-two women with newly diagnosed breast cancer (without distant metastasis), eligible for adjuvant/neoadjuvant chemotherapy (cyclophosphamide and adriamycin, 4 cycles × 3 weeks), were included in this study. All the observations were noted before, during (after 6 weeks of starting chemotherapy), and after the completion of chemotherapy (after 12 weeks of starting chemotherapy). Statistical Analysis Used: Variables such as mucositis, salivary flow rate, salivary pH, and candidal carriage rate were compared at baseline, and at 1st and 2nd follow-ups using Wilcoxon signed-rank test (P value corrected for α for pair-wise comparisons). Results: Mean unstimulated whole salivary flow rate reduced from 0.5 ml/min to 0.3 ml/min, and the mean colony-forming units of Candida reduced from 32.3 × 103 cells/ml to 13.1 × 103 cells/ml at the end of the study period. Xerostomia, taste disturbances, and oral mucosal pigmentation increased from 28.8% to 50%. Conclusions: There was a discernible change in oral mucosal, salivary, and candidal status during the course of the study.

UR - http://www.scopus.com/inward/record.url?scp=85026218418&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85026218418&partnerID=8YFLogxK

U2 - 10.4103/ijdr.IJDR-379-16

DO - 10.4103/ijdr.IJDR-379-16

M3 - Article

VL - 28

SP - 261

EP - 268

JO - Indian Journal of Dental Research

JF - Indian Journal of Dental Research

SN - 0970-9290

IS - 3

ER -