TY - JOUR
T1 - Organic quantum dots
T2 - An ultrasmall nanoplatform for cancer theranostics
AU - Dhas, Namdev
AU - Pastagia, Monarch
AU - Sharma, Akanksha
AU - Khera, Alisha
AU - Kudarha, Ritu
AU - Kulkarni, Sanjay
AU - Soman, Soji
AU - Mutalik, Srinivas
AU - Barnwal, Ravi Pratap
AU - Singh, Gurpal
AU - Patel, Mital
N1 - Copyright © 2022 Elsevier B.V. All rights reserved.
PY - 2022/8
Y1 - 2022/8
N2 - Tumours are the second leading cause of death globally, generating alterations in biological interactions and, as a result, malfunctioning of crucial genetic traits. Technological advancements have made it possible to identify tumours at the cellular level, making transcriptional gene variations and other genetic variables more easily investigated. Standard chemotherapy is seen as a non-specific treatment that has the potential to destroy healthy cells while also causing systemic toxicity in individuals. As a result, developing new technologies has become a pressing necessity. QDs are semiconductor particles with diameters ranging from 2 to 10 nanometers. QDs have grabbed the interest of many researchers due to their unique characteristics, including compact size, large surface area, surface charges, and precise targeting. QD-based drug carriers are well known among the many nanocarriers. Using QDs as a delivery approach enhances solubility, lengthens retention time, and reduces the harmful effects of loaded medicines. Several varieties of quantum dots used in drug administration are discussed in this article, along with their chemical and physical characteristics and manufacturing methods. Furthermore, it discusses the role of QDs in biological, medicinal, and theranostic applications.
AB - Tumours are the second leading cause of death globally, generating alterations in biological interactions and, as a result, malfunctioning of crucial genetic traits. Technological advancements have made it possible to identify tumours at the cellular level, making transcriptional gene variations and other genetic variables more easily investigated. Standard chemotherapy is seen as a non-specific treatment that has the potential to destroy healthy cells while also causing systemic toxicity in individuals. As a result, developing new technologies has become a pressing necessity. QDs are semiconductor particles with diameters ranging from 2 to 10 nanometers. QDs have grabbed the interest of many researchers due to their unique characteristics, including compact size, large surface area, surface charges, and precise targeting. QD-based drug carriers are well known among the many nanocarriers. Using QDs as a delivery approach enhances solubility, lengthens retention time, and reduces the harmful effects of loaded medicines. Several varieties of quantum dots used in drug administration are discussed in this article, along with their chemical and physical characteristics and manufacturing methods. Furthermore, it discusses the role of QDs in biological, medicinal, and theranostic applications.
UR - http://www.scopus.com/inward/record.url?scp=85133633720&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85133633720&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2022.06.033
DO - 10.1016/j.jconrel.2022.06.033
M3 - Review article
C2 - 35752250
AN - SCOPUS:85133633720
SN - 0168-3659
VL - 348
SP - 798
EP - 824
JO - Journal of Controlled Release
JF - Journal of Controlled Release
ER -