Outcome of mood stabilizer discontinuation in bipolar disorder after 5 years of euthymia

P. S V N Sharma, Sreejayan Kongasseri, Samir Kumar Praharaj

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

OBJECTIVE: The objective was to study the outcome of mood stabilizer discontinuation on recurrence in patients with bipolar disorder after at least 5 years of euthymia. METHODS: Twenty-three patients diagnosed with bipolar affective disorder according to the International Classification of Diseases, 10th Revision Diagnostic Criteria for Research, receiving mood stabilizer prophylaxis for at least 5 years, had undergone planned discontinuation, and the rates and time to recurrence were studied. RESULTS: Twenty (87%) of 23 patients had recurrence, and all of the episodes were manic. Kaplan-Meier survival analysis showed median time to recurrence following discontinuation of mood stabilizer prophylaxis was 10 months (SE, 6.06 months; 95% confidence interval, 0 to 21.89 months). CONCLUSION: Four fifths of our patients had recurrence following discontinuation of mood stabilizer prophylaxis within 10 months.

Original languageEnglish
Pages (from-to)504-507
Number of pages4
JournalJournal of Clinical Psychopharmacology
Volume34
Issue number4
DOIs
Publication statusPublished - 01-01-2014

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Bipolar Disorder
Recurrence
Kaplan-Meier Estimate
International Classification of Diseases
Survival Analysis
Mood Disorders
Outcome Assessment (Health Care)
Confidence Intervals
Research

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Medicine(all)

Cite this

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Outcome of mood stabilizer discontinuation in bipolar disorder after 5 years of euthymia. / Sharma, P. S V N; Kongasseri, Sreejayan; Praharaj, Samir Kumar.

In: Journal of Clinical Psychopharmacology, Vol. 34, No. 4, 01.01.2014, p. 504-507.

Research output: Contribution to journalArticle

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AB - OBJECTIVE: The objective was to study the outcome of mood stabilizer discontinuation on recurrence in patients with bipolar disorder after at least 5 years of euthymia. METHODS: Twenty-three patients diagnosed with bipolar affective disorder according to the International Classification of Diseases, 10th Revision Diagnostic Criteria for Research, receiving mood stabilizer prophylaxis for at least 5 years, had undergone planned discontinuation, and the rates and time to recurrence were studied. RESULTS: Twenty (87%) of 23 patients had recurrence, and all of the episodes were manic. Kaplan-Meier survival analysis showed median time to recurrence following discontinuation of mood stabilizer prophylaxis was 10 months (SE, 6.06 months; 95% confidence interval, 0 to 21.89 months). CONCLUSION: Four fifths of our patients had recurrence following discontinuation of mood stabilizer prophylaxis within 10 months.

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