Ovarian dysgerminoma- A retrospective analysis of treatment results

Objectives: A retrospective review of the clinical presentation, management and survival of patients with pure ovarian dysgerminoma. Materials and Methods: Twenty-six patients with pure ovarian dysgerminoma were treated between 1983 and 1990. Fifteen patients had stage I, four had stage II, six had stage III and, one patient had stage IV disease. All patients were followed up for a minimum of 2.4 years (median follow up 3.6 years). Twenty- three stage I-III patients received post-operative radiotherapy. Results: Overall survival at three and six years for the entire group was 89% and 84% respectively. Six patients relapsed: two with stage I, one with stage II and, three with stage III disease. All but one of the relapses occurred within two years of diagnosis. The only patient with stage IV disease was treated with chemotherapy and remains disease free. Conclusions: Ovarian dysgerminomas are extremely sensitive to radiation therapy and chemotherapy. The overall survival rate of 84% at six years for patients with dysgerminoma treated at our center compares well with reported survival rates in other studies.