Oxidant-antioxidant status in colorectal cancer patients - Before and after treatment

Sharmila Upadhya, Subramanya Upadhya, S. Krishna Mohan, K. Vanajakshamma, Mamatha Kunder, Seema Mathias

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Abstract

Erythrocyte antioxidant glutathione and malondialdehyde levels in erythrocytes and plasma glutathione S-transferase levels were estimated in patients with colorectal cancer and compared to controls. Further, the patients underwent four weeks of radiotherapy with adjuvant chemotherapy. The same parameters were estimated after four weeks of radiotherapy and compared with pretreatment levels. It was observed that there was a decrease in erythrocyte glutathione and malondialdehyde levels in patients with colorectal cancer compared to controls, but not in case of GST. However, after chemoradiotherapy, there were no statistically significant differences in all the parameters studied.

Original languageEnglish
Pages (from-to)80-83
Number of pages4
JournalIndian Journal of Clinical Biochemistry
Volume19
Issue number2
DOIs
Publication statusPublished - 01-01-2004
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Upadhya, S., Upadhya, S., Mohan, S. K., Vanajakshamma, K., Kunder, M., & Mathias, S. (2004). Oxidant-antioxidant status in colorectal cancer patients - Before and after treatment. Indian Journal of Clinical Biochemistry, 19(2), 80-83. https://doi.org/10.1007/BF02894261