Oxidative injury and antioxidant vitamins E and C in Schizophrenia

Benedicta D'Souza, Vivian D'Souza

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


Susceptibility of Schizophrenic patients to lipid peroxidation relative to healthy control subjects was investigated by measuring the malondialdehyde (MDA) levels in plasma. The main finding was that Schizophrenic patients were more susceptible than control subjects to oxidative damage as evident from increased MDA levels in plasma. Antioxidant levels are also depleted in Schizophrenic patients when compared to normal subjects as evident from decreased levels of vitamins E and C in the plasma. Impaired antioxidant defense and increased lipid peroxidation suggests that treatment with antioxidants (Vitamin E, Vitamin C, beta carotene) at the initial stages of illness may prevent further oxidative injury and deterioration of associated neurological deficits in Schizophrenia.

Original languageEnglish
Pages (from-to)87-90
Number of pages4
JournalIndian Journal of Clinical Biochemistry
Issue number1
Publication statusPublished - 01-01-2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry


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