Oxidative products of proteins and antioxidant potential of thiols in gastric carcinoma patients

Anita Mukthapura, Avinash Shimogga, Vinodchandran Sudha K, Beena Shetty, Gayathri M. Rao

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

It has been suggested that oxidative stress defined as a shift in antioxidant/oxidant balance towards oxidants is associated with the pathogenesis of many diseases, including carcinogenesis. Reactive oxygen species can induce carcinogenesis via injury to macromolecules such as DNA, carbohydrates and proteins. Forty primary gastric carcinoma patients and 40 healthy controls were included in the study. Advanced oxidation protein products, total thiols, total protein, albumin in plasma, % hemolysis in RBC suspension and glutathione in both whole blood and plasma were estimated. Our studies demonstrated a significant increase in advanced oxidation protein products, % hemolysis (p=0.033), A:G ratio (p=0.003) and a highly significant decrease in blood glutathione (p=0.036), total thiols (p=0.001), plasma thiols other than glutathione and total antioxidant activity. The findings suggest that gastric carcinoma is associated with oxygen derived free radicals accumulation, and depletion of total antioxidant activity has lead to oxidative stress and advancement of oxidative-antioxidative disorders followed by progression of gastric cancer.

Original languageEnglish
Pages (from-to)102-106
Number of pages5
JournalJournal of Medical Biochemistry
Volume29
Issue number2
DOIs
Publication statusPublished - 01-04-2010

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Advanced Oxidation Protein Products
Sulfhydryl Compounds
Glutathione
Stomach
Oxidative stress
Antioxidants
Hemolysis
Carcinoma
Plasmas
Oxidants
Carcinogenesis
Oxidative Stress
Blood
Proteins
Macromolecules
Serum Albumin
Stomach Neoplasms
Free Radicals
Albumins
Reactive Oxygen Species

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

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abstract = "It has been suggested that oxidative stress defined as a shift in antioxidant/oxidant balance towards oxidants is associated with the pathogenesis of many diseases, including carcinogenesis. Reactive oxygen species can induce carcinogenesis via injury to macromolecules such as DNA, carbohydrates and proteins. Forty primary gastric carcinoma patients and 40 healthy controls were included in the study. Advanced oxidation protein products, total thiols, total protein, albumin in plasma, {\%} hemolysis in RBC suspension and glutathione in both whole blood and plasma were estimated. Our studies demonstrated a significant increase in advanced oxidation protein products, {\%} hemolysis (p=0.033), A:G ratio (p=0.003) and a highly significant decrease in blood glutathione (p=0.036), total thiols (p=0.001), plasma thiols other than glutathione and total antioxidant activity. The findings suggest that gastric carcinoma is associated with oxygen derived free radicals accumulation, and depletion of total antioxidant activity has lead to oxidative stress and advancement of oxidative-antioxidative disorders followed by progression of gastric cancer.",
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Oxidative products of proteins and antioxidant potential of thiols in gastric carcinoma patients. / Mukthapura, Anita; Shimogga, Avinash; Sudha K, Vinodchandran; Shetty, Beena; Rao, Gayathri M.

In: Journal of Medical Biochemistry, Vol. 29, No. 2, 01.04.2010, p. 102-106.

Research output: Contribution to journalArticle

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