Oxidative stress and antioxidants in tubercular meningitis

K. Sudha, Ashalatha V. Rao, S. N. Rao, Anjali Rao

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Oxidative stress is implicated in the etiopathogenesis of a variety of human diseases. Therefore, in the present study, erythrocyte lipid peroxidation, percentage hemolysis, antioxidant enzymes viz., glutathione reductase, glutathione peroxidase, superoxide dismutase and plasma antioxidants viz., ceruloplasmin, vitamins A,E and C have been determined in 19 patients with tubercular meningitis (TBM) and 50 normals. Six patients who were treated with antibiotics were considered for the follow up. The statistical analysis was carried out by Mann Whitney U test and Wilcoxon rank sum test. Lipid peroxidation (P<0.02), percentage hemolysis (P<0.001) and plasma ceruloplasmin (P<0.0001) of TBM patients were significantly higher, whereas erythrocyte glutathione reductase (P<0.05) and plasma antioxidant vitamins A, E and C (P<0.01, P<0.05 respectively) were significantly lower than those of the controls. In the follow up patients the glutathione reductase and catalase levels were significantly high (P<0.05) compared to their pre-treated condition. Vitamin C and E levels have attained normal range. This study indicated that the blood antioxidant status of TBM patients which was low compared to controls improved after treatment, suggesting the role of free radicals in TBM.

Original languageEnglish
Pages (from-to)34-41
Number of pages8
JournalIndian Journal of Clinical Biochemistry
Volume17
Issue number1
DOIs
Publication statusPublished - 01-01-2002

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Meningeal Tuberculosis
Oxidative stress
Glutathione Reductase
Oxidative Stress
Antioxidants
Nonparametric Statistics
Ceruloplasmin
Vitamin E
Ascorbic Acid
Vitamin A
Plasmas
Hemolysis
Lipid Peroxidation
Lipids
Erythrocytes
Glutathione Peroxidase
Catalase
Superoxide Dismutase
Free Radicals
Statistical methods

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Sudha, K. ; Rao, Ashalatha V. ; Rao, S. N. ; Rao, Anjali. / Oxidative stress and antioxidants in tubercular meningitis. In: Indian Journal of Clinical Biochemistry. 2002 ; Vol. 17, No. 1. pp. 34-41.
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Oxidative stress and antioxidants in tubercular meningitis. / Sudha, K.; Rao, Ashalatha V.; Rao, S. N.; Rao, Anjali.

In: Indian Journal of Clinical Biochemistry, Vol. 17, No. 1, 01.01.2002, p. 34-41.

Research output: Contribution to journalArticle

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