Abstract

Diabetes mellitus is a major risk factor for the development of cataract and oxidative stress is thought to be a major factor to initiate this process. The transparency of lens depends on optimum concentration of intracellular calcium, which is altered by the process of oxidative stress. The main objective of the present study is to compare level of oxidative stress markers in both senile and diabetic cataract patients. Serum was analyzed for MDA, total antioxidant activity [AOA], and total calcium, while lens was analyzed for AOA and total calcium. There was a significant increase in serum MDA (p<0.001) in patients with diabetic cataract. Antioxidant activity was significantly reduced in serum (p<0.05) as well as lens (p<0.01) in these patients. However there was no significant change in the serum and lens calcium levels. Comparison between mature and immature cataractous lenses showed a significant increase in the calcium and decrease in antioxidant activity. A positive association of lens calcium with serum MDA (r=0.714) was observed. Thus, it is inferred that diabetic patients are subjected to oxidative stress at much earlier age than compared to senile cataract patients.

Original languageEnglish
Pages (from-to)109-116
Number of pages8
JournalInternational Journal of Pharma and Bio Sciences
Volume2
Issue number1
Publication statusPublished - 2011

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Oxidative stress
Cataract
Lenses
Oxidative Stress
Calcium
Antioxidants
Serum
Medical problems
Transparency
Diabetes Mellitus
Association reactions

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

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title = "Oxidative stress and calcium levels in senile and type 2 diabetic: Cataract patients",
abstract = "Diabetes mellitus is a major risk factor for the development of cataract and oxidative stress is thought to be a major factor to initiate this process. The transparency of lens depends on optimum concentration of intracellular calcium, which is altered by the process of oxidative stress. The main objective of the present study is to compare level of oxidative stress markers in both senile and diabetic cataract patients. Serum was analyzed for MDA, total antioxidant activity [AOA], and total calcium, while lens was analyzed for AOA and total calcium. There was a significant increase in serum MDA (p<0.001) in patients with diabetic cataract. Antioxidant activity was significantly reduced in serum (p<0.05) as well as lens (p<0.01) in these patients. However there was no significant change in the serum and lens calcium levels. Comparison between mature and immature cataractous lenses showed a significant increase in the calcium and decrease in antioxidant activity. A positive association of lens calcium with serum MDA (r=0.714) was observed. Thus, it is inferred that diabetic patients are subjected to oxidative stress at much earlier age than compared to senile cataract patients.",
author = "K. Deepa and {Manjunatha Goud}, {B. K.} and M. Nandini and Asha Kamath and Sudhir and Bhavna Nayal",
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Oxidative stress and calcium levels in senile and type 2 diabetic : Cataract patients. / Deepa, K.; Manjunatha Goud, B. K.; Nandini, M.; Kamath, Asha; Sudhir, ; Nayal, Bhavna.

In: International Journal of Pharma and Bio Sciences, Vol. 2, No. 1, 2011, p. 109-116.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Oxidative stress and calcium levels in senile and type 2 diabetic

T2 - Cataract patients

AU - Deepa, K.

AU - Manjunatha Goud, B. K.

AU - Nandini, M.

AU - Kamath, Asha

AU - Sudhir,

AU - Nayal, Bhavna

PY - 2011

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N2 - Diabetes mellitus is a major risk factor for the development of cataract and oxidative stress is thought to be a major factor to initiate this process. The transparency of lens depends on optimum concentration of intracellular calcium, which is altered by the process of oxidative stress. The main objective of the present study is to compare level of oxidative stress markers in both senile and diabetic cataract patients. Serum was analyzed for MDA, total antioxidant activity [AOA], and total calcium, while lens was analyzed for AOA and total calcium. There was a significant increase in serum MDA (p<0.001) in patients with diabetic cataract. Antioxidant activity was significantly reduced in serum (p<0.05) as well as lens (p<0.01) in these patients. However there was no significant change in the serum and lens calcium levels. Comparison between mature and immature cataractous lenses showed a significant increase in the calcium and decrease in antioxidant activity. A positive association of lens calcium with serum MDA (r=0.714) was observed. Thus, it is inferred that diabetic patients are subjected to oxidative stress at much earlier age than compared to senile cataract patients.

AB - Diabetes mellitus is a major risk factor for the development of cataract and oxidative stress is thought to be a major factor to initiate this process. The transparency of lens depends on optimum concentration of intracellular calcium, which is altered by the process of oxidative stress. The main objective of the present study is to compare level of oxidative stress markers in both senile and diabetic cataract patients. Serum was analyzed for MDA, total antioxidant activity [AOA], and total calcium, while lens was analyzed for AOA and total calcium. There was a significant increase in serum MDA (p<0.001) in patients with diabetic cataract. Antioxidant activity was significantly reduced in serum (p<0.05) as well as lens (p<0.01) in these patients. However there was no significant change in the serum and lens calcium levels. Comparison between mature and immature cataractous lenses showed a significant increase in the calcium and decrease in antioxidant activity. A positive association of lens calcium with serum MDA (r=0.714) was observed. Thus, it is inferred that diabetic patients are subjected to oxidative stress at much earlier age than compared to senile cataract patients.

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