Oxidative stress and DNA single strand breaks in skeletal muscle of aged rats

Role of carnitine and lipoicacid

Kumaran Sundaram, Kavin S. Panneerselvam

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The exposure of biological system to various conditions of oxidative stress is the major contributor for aging process. Oxidative stress in turn increases the cellular levels of oxidatively modified proteins, lipids and nucleic acids resulting in a loss of physical activity and metabolic integrity. In this study, we evaluated the role of L-carnitine and DL-α-lipoic acid in minimizing oxidant generation and macromolecular damage in skeletal muscle of aged rats. We found that the oxidant generation was increased in aged rat skeletal muscle when compared to young rats. There was a simultaneous increase in the levels of lipid peroxidation, protein carbonyl content and DNA strand breaks in aged rat skeletal muscle. Administration of L-carnitine (300 mg/kg body wt/day) and DL-α-lipoic acid (100 mg/kg body wt/day) to aged rats for 30 days, decreased the oxidant generation, lipid peroxidation, protein carbonylation and DNA strand breaks. We concluded that co-administration of carnitine and lipoic acid to aged rats has the potential to prevent oxidative stress mediated macromolecular damage in skeletal muscle of aged rats by their putative role as efficient antioxidants.

Original languageEnglish
Pages (from-to)111-118
Number of pages8
JournalBiogerontology
Volume7
Issue number2
DOIs
Publication statusPublished - 01-04-2006
Externally publishedYes

Fingerprint

Single-Stranded DNA Breaks
Carnitine
Skeletal Muscle
Oxidative Stress
Thioctic Acid
Oxidants
DNA Breaks
Lipid Peroxidation
Protein Carbonylation
Nucleic Acids
Proteins
Antioxidants
Lipids

All Science Journal Classification (ASJC) codes

  • Ageing
  • Gerontology
  • Geriatrics and Gerontology

Cite this

Sundaram, Kumaran ; Panneerselvam, Kavin S. / Oxidative stress and DNA single strand breaks in skeletal muscle of aged rats : Role of carnitine and lipoicacid. In: Biogerontology. 2006 ; Vol. 7, No. 2. pp. 111-118.
@article{f3a0f6fad4b84ea6acbb8ebf733250fc,
title = "Oxidative stress and DNA single strand breaks in skeletal muscle of aged rats: Role of carnitine and lipoicacid",
abstract = "The exposure of biological system to various conditions of oxidative stress is the major contributor for aging process. Oxidative stress in turn increases the cellular levels of oxidatively modified proteins, lipids and nucleic acids resulting in a loss of physical activity and metabolic integrity. In this study, we evaluated the role of L-carnitine and DL-α-lipoic acid in minimizing oxidant generation and macromolecular damage in skeletal muscle of aged rats. We found that the oxidant generation was increased in aged rat skeletal muscle when compared to young rats. There was a simultaneous increase in the levels of lipid peroxidation, protein carbonyl content and DNA strand breaks in aged rat skeletal muscle. Administration of L-carnitine (300 mg/kg body wt/day) and DL-α-lipoic acid (100 mg/kg body wt/day) to aged rats for 30 days, decreased the oxidant generation, lipid peroxidation, protein carbonylation and DNA strand breaks. We concluded that co-administration of carnitine and lipoic acid to aged rats has the potential to prevent oxidative stress mediated macromolecular damage in skeletal muscle of aged rats by their putative role as efficient antioxidants.",
author = "Kumaran Sundaram and Panneerselvam, {Kavin S.}",
year = "2006",
month = "4",
day = "1",
doi = "10.1007/s10522-006-0002-2",
language = "English",
volume = "7",
pages = "111--118",
journal = "Biogerontology",
issn = "1389-5729",
publisher = "Springer Netherlands",
number = "2",

}

Oxidative stress and DNA single strand breaks in skeletal muscle of aged rats : Role of carnitine and lipoicacid. / Sundaram, Kumaran; Panneerselvam, Kavin S.

In: Biogerontology, Vol. 7, No. 2, 01.04.2006, p. 111-118.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Oxidative stress and DNA single strand breaks in skeletal muscle of aged rats

T2 - Role of carnitine and lipoicacid

AU - Sundaram, Kumaran

AU - Panneerselvam, Kavin S.

PY - 2006/4/1

Y1 - 2006/4/1

N2 - The exposure of biological system to various conditions of oxidative stress is the major contributor for aging process. Oxidative stress in turn increases the cellular levels of oxidatively modified proteins, lipids and nucleic acids resulting in a loss of physical activity and metabolic integrity. In this study, we evaluated the role of L-carnitine and DL-α-lipoic acid in minimizing oxidant generation and macromolecular damage in skeletal muscle of aged rats. We found that the oxidant generation was increased in aged rat skeletal muscle when compared to young rats. There was a simultaneous increase in the levels of lipid peroxidation, protein carbonyl content and DNA strand breaks in aged rat skeletal muscle. Administration of L-carnitine (300 mg/kg body wt/day) and DL-α-lipoic acid (100 mg/kg body wt/day) to aged rats for 30 days, decreased the oxidant generation, lipid peroxidation, protein carbonylation and DNA strand breaks. We concluded that co-administration of carnitine and lipoic acid to aged rats has the potential to prevent oxidative stress mediated macromolecular damage in skeletal muscle of aged rats by their putative role as efficient antioxidants.

AB - The exposure of biological system to various conditions of oxidative stress is the major contributor for aging process. Oxidative stress in turn increases the cellular levels of oxidatively modified proteins, lipids and nucleic acids resulting in a loss of physical activity and metabolic integrity. In this study, we evaluated the role of L-carnitine and DL-α-lipoic acid in minimizing oxidant generation and macromolecular damage in skeletal muscle of aged rats. We found that the oxidant generation was increased in aged rat skeletal muscle when compared to young rats. There was a simultaneous increase in the levels of lipid peroxidation, protein carbonyl content and DNA strand breaks in aged rat skeletal muscle. Administration of L-carnitine (300 mg/kg body wt/day) and DL-α-lipoic acid (100 mg/kg body wt/day) to aged rats for 30 days, decreased the oxidant generation, lipid peroxidation, protein carbonylation and DNA strand breaks. We concluded that co-administration of carnitine and lipoic acid to aged rats has the potential to prevent oxidative stress mediated macromolecular damage in skeletal muscle of aged rats by their putative role as efficient antioxidants.

UR - http://www.scopus.com/inward/record.url?scp=33745512149&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745512149&partnerID=8YFLogxK

U2 - 10.1007/s10522-006-0002-2

DO - 10.1007/s10522-006-0002-2

M3 - Article

VL - 7

SP - 111

EP - 118

JO - Biogerontology

JF - Biogerontology

SN - 1389-5729

IS - 2

ER -