Oxidative stress in pediatric nephrotic syndrome

Rajani Kamireddy, Suchitra Kavuri, Sri Devi, Harathi Vemula, Devi Chandana, Salini Harinarayanan, Reena James, Anjali Rao

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Nephrotic syndrome (NS) is a stressful condition for children where oxidative damage would also influence the response of these patients to therapy. Methods: The present study was conducted in children with nephrotic syndrome during relapse and remission and in 10 age- and sex-matched healthy volunteers. Red cell glutathione (GSH), superoxide dismutase (SOD) and malondialdehyde (MDA) concentrations as well as plasma ceruloplasmin (CP) and vitamin E concentrations were analyzed in controls and in patients. Results: Erythrocyte superoxide dismutase concentrations were significantly increased in both the groups when compared to controls. Erythrocyte glutathione significantly decreased in nephrotic syndrome in remission along with plasma vitamin E concentrations in both the groups. A significant increase in plasma ceruloplasmin was observed in cases in remission. However, no significant change was observed in the concentrations of erythrocyte malondialdehyde. Conclusion: Thus, antioxidant concentrations change considerably, indicating a compensatory mechanism to cope up with increased pro-oxidant status in such cases.

Original languageEnglish
Pages (from-to)147-150
Number of pages4
JournalClinica Chimica Acta
Volume325
Issue number1-2
DOIs
Publication statusPublished - 01-11-2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry

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    Kamireddy, R., Kavuri, S., Devi, S., Vemula, H., Chandana, D., Harinarayanan, S., James, R., & Rao, A. (2002). Oxidative stress in pediatric nephrotic syndrome. Clinica Chimica Acta, 325(1-2), 147-150. https://doi.org/10.1016/S0009-8981(02)00294-2