Oxidative stress in pediatric nephrotic syndrome

Rajani Kamireddy, Suchitra Kavuri, Sri Devi, Harathi Vemula, Devi Chandana, Salini Harinarayanan, Reena James, Anjali Rao

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Nephrotic syndrome (NS) is a stressful condition for children where oxidative damage would also influence the response of these patients to therapy. Methods: The present study was conducted in children with nephrotic syndrome during relapse and remission and in 10 age- and sex-matched healthy volunteers. Red cell glutathione (GSH), superoxide dismutase (SOD) and malondialdehyde (MDA) concentrations as well as plasma ceruloplasmin (CP) and vitamin E concentrations were analyzed in controls and in patients. Results: Erythrocyte superoxide dismutase concentrations were significantly increased in both the groups when compared to controls. Erythrocyte glutathione significantly decreased in nephrotic syndrome in remission along with plasma vitamin E concentrations in both the groups. A significant increase in plasma ceruloplasmin was observed in cases in remission. However, no significant change was observed in the concentrations of erythrocyte malondialdehyde. Conclusion: Thus, antioxidant concentrations change considerably, indicating a compensatory mechanism to cope up with increased pro-oxidant status in such cases.

Original languageEnglish
Pages (from-to)147-150
Number of pages4
JournalClinica Chimica Acta
Volume325
Issue number1-2
DOIs
Publication statusPublished - 01-11-2002
Externally publishedYes

Fingerprint

Pediatrics
Oxidative stress
Nephrotic Syndrome
Oxidative Stress
Ceruloplasmin
Erythrocytes
Malondialdehyde
Vitamin E
Plasmas
Superoxide Dismutase
Glutathione
Reactive Oxygen Species
Healthy Volunteers
Antioxidants
Cells
Recurrence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry

Cite this

Kamireddy, R., Kavuri, S., Devi, S., Vemula, H., Chandana, D., Harinarayanan, S., ... Rao, A. (2002). Oxidative stress in pediatric nephrotic syndrome. Clinica Chimica Acta, 325(1-2), 147-150. https://doi.org/10.1016/S0009-8981(02)00294-2
Kamireddy, Rajani ; Kavuri, Suchitra ; Devi, Sri ; Vemula, Harathi ; Chandana, Devi ; Harinarayanan, Salini ; James, Reena ; Rao, Anjali. / Oxidative stress in pediatric nephrotic syndrome. In: Clinica Chimica Acta. 2002 ; Vol. 325, No. 1-2. pp. 147-150.
@article{a2ef9d64eed94f4ca8d0f9e6b4a750cc,
title = "Oxidative stress in pediatric nephrotic syndrome",
abstract = "Background: Nephrotic syndrome (NS) is a stressful condition for children where oxidative damage would also influence the response of these patients to therapy. Methods: The present study was conducted in children with nephrotic syndrome during relapse and remission and in 10 age- and sex-matched healthy volunteers. Red cell glutathione (GSH), superoxide dismutase (SOD) and malondialdehyde (MDA) concentrations as well as plasma ceruloplasmin (CP) and vitamin E concentrations were analyzed in controls and in patients. Results: Erythrocyte superoxide dismutase concentrations were significantly increased in both the groups when compared to controls. Erythrocyte glutathione significantly decreased in nephrotic syndrome in remission along with plasma vitamin E concentrations in both the groups. A significant increase in plasma ceruloplasmin was observed in cases in remission. However, no significant change was observed in the concentrations of erythrocyte malondialdehyde. Conclusion: Thus, antioxidant concentrations change considerably, indicating a compensatory mechanism to cope up with increased pro-oxidant status in such cases.",
author = "Rajani Kamireddy and Suchitra Kavuri and Sri Devi and Harathi Vemula and Devi Chandana and Salini Harinarayanan and Reena James and Anjali Rao",
year = "2002",
month = "11",
day = "1",
doi = "10.1016/S0009-8981(02)00294-2",
language = "English",
volume = "325",
pages = "147--150",
journal = "Clinica Chimica Acta",
issn = "0009-8981",
publisher = "Elsevier",
number = "1-2",

}

Kamireddy, R, Kavuri, S, Devi, S, Vemula, H, Chandana, D, Harinarayanan, S, James, R & Rao, A 2002, 'Oxidative stress in pediatric nephrotic syndrome', Clinica Chimica Acta, vol. 325, no. 1-2, pp. 147-150. https://doi.org/10.1016/S0009-8981(02)00294-2

Oxidative stress in pediatric nephrotic syndrome. / Kamireddy, Rajani; Kavuri, Suchitra; Devi, Sri; Vemula, Harathi; Chandana, Devi; Harinarayanan, Salini; James, Reena; Rao, Anjali.

In: Clinica Chimica Acta, Vol. 325, No. 1-2, 01.11.2002, p. 147-150.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Oxidative stress in pediatric nephrotic syndrome

AU - Kamireddy, Rajani

AU - Kavuri, Suchitra

AU - Devi, Sri

AU - Vemula, Harathi

AU - Chandana, Devi

AU - Harinarayanan, Salini

AU - James, Reena

AU - Rao, Anjali

PY - 2002/11/1

Y1 - 2002/11/1

N2 - Background: Nephrotic syndrome (NS) is a stressful condition for children where oxidative damage would also influence the response of these patients to therapy. Methods: The present study was conducted in children with nephrotic syndrome during relapse and remission and in 10 age- and sex-matched healthy volunteers. Red cell glutathione (GSH), superoxide dismutase (SOD) and malondialdehyde (MDA) concentrations as well as plasma ceruloplasmin (CP) and vitamin E concentrations were analyzed in controls and in patients. Results: Erythrocyte superoxide dismutase concentrations were significantly increased in both the groups when compared to controls. Erythrocyte glutathione significantly decreased in nephrotic syndrome in remission along with plasma vitamin E concentrations in both the groups. A significant increase in plasma ceruloplasmin was observed in cases in remission. However, no significant change was observed in the concentrations of erythrocyte malondialdehyde. Conclusion: Thus, antioxidant concentrations change considerably, indicating a compensatory mechanism to cope up with increased pro-oxidant status in such cases.

AB - Background: Nephrotic syndrome (NS) is a stressful condition for children where oxidative damage would also influence the response of these patients to therapy. Methods: The present study was conducted in children with nephrotic syndrome during relapse and remission and in 10 age- and sex-matched healthy volunteers. Red cell glutathione (GSH), superoxide dismutase (SOD) and malondialdehyde (MDA) concentrations as well as plasma ceruloplasmin (CP) and vitamin E concentrations were analyzed in controls and in patients. Results: Erythrocyte superoxide dismutase concentrations were significantly increased in both the groups when compared to controls. Erythrocyte glutathione significantly decreased in nephrotic syndrome in remission along with plasma vitamin E concentrations in both the groups. A significant increase in plasma ceruloplasmin was observed in cases in remission. However, no significant change was observed in the concentrations of erythrocyte malondialdehyde. Conclusion: Thus, antioxidant concentrations change considerably, indicating a compensatory mechanism to cope up with increased pro-oxidant status in such cases.

UR - http://www.scopus.com/inward/record.url?scp=0036842227&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036842227&partnerID=8YFLogxK

U2 - 10.1016/S0009-8981(02)00294-2

DO - 10.1016/S0009-8981(02)00294-2

M3 - Article

VL - 325

SP - 147

EP - 150

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

SN - 0009-8981

IS - 1-2

ER -

Kamireddy R, Kavuri S, Devi S, Vemula H, Chandana D, Harinarayanan S et al. Oxidative stress in pediatric nephrotic syndrome. Clinica Chimica Acta. 2002 Nov 1;325(1-2):147-150. https://doi.org/10.1016/S0009-8981(02)00294-2