Pancytopenia in multiple myeloma-An Enigma

Our experience from tertiary care hospital

Hanaganahalli B. Sridevi, Sharada Rai, Pooja K. Suresh, Meludurgamutt S. Somesh, Jessica Minal

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Introduction: Multiple myeloma is a plasma cell neoplasm that is characterized by clonal proliferation of malignant plasma cell in the bone marrow along with M-protein in the serum and/or urine. Pancytopenia as a initial presentation of multiple myeloma is quite unusual. We are presenting a case series having pancytopenia as the presenting complaint. Materials and Methods: A retrospective study was conducted for a period of 30 months, wherein all the cases of multiple myeloma presenting with pancytopenia were included. The complete blood picture, peripheral smear examination, bone marrow aspirate & protein electrophoresis of all the cases were reviewed & analysed. Results: During the study period, 10 cases presented with pancytopenia with a mean age of 66.3 years (range: 59-72 years) at presentation with male: female ratio being 8:2. Fatigue and weakness was the most common symptom (100%) & average ESR was 104 mm/hour. High-resolution serum electrophoresis, showed a dense, sharp to wide M band in the gamma globulin region. Bone marrow plasma cell percentage was increased with an average of 63.1%. Bone marrow biopsy correlation was obtained in 100% cases. Conclusion: Diagnosing multiple myeloma, presenting as pancytopenia requires a high degree of suspicion to avoid delay in initiation of treatment.

Original languageEnglish
Pages (from-to)EC04-EC06
JournalJournal of Clinical and Diagnostic Research
Volume9
Issue number11
DOIs
Publication statusPublished - 01-11-2015

Fingerprint

Pancytopenia
Tertiary Healthcare
Multiple Myeloma
Tertiary Care Centers
Bone
Electrophoresis
Plasmas
Plasma Cells
Plasma Cell Neoplasms
Bone Marrow
Biopsy
gamma-Globulins
Bone Marrow Examination
Paramagnetic resonance
Proteins
Blood
Bone Marrow Cells
Fatigue of materials
Fatigue
Blood Proteins

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

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title = "Pancytopenia in multiple myeloma-An Enigma: Our experience from tertiary care hospital",
abstract = "Introduction: Multiple myeloma is a plasma cell neoplasm that is characterized by clonal proliferation of malignant plasma cell in the bone marrow along with M-protein in the serum and/or urine. Pancytopenia as a initial presentation of multiple myeloma is quite unusual. We are presenting a case series having pancytopenia as the presenting complaint. Materials and Methods: A retrospective study was conducted for a period of 30 months, wherein all the cases of multiple myeloma presenting with pancytopenia were included. The complete blood picture, peripheral smear examination, bone marrow aspirate & protein electrophoresis of all the cases were reviewed & analysed. Results: During the study period, 10 cases presented with pancytopenia with a mean age of 66.3 years (range: 59-72 years) at presentation with male: female ratio being 8:2. Fatigue and weakness was the most common symptom (100{\%}) & average ESR was 104 mm/hour. High-resolution serum electrophoresis, showed a dense, sharp to wide M band in the gamma globulin region. Bone marrow plasma cell percentage was increased with an average of 63.1{\%}. Bone marrow biopsy correlation was obtained in 100{\%} cases. Conclusion: Diagnosing multiple myeloma, presenting as pancytopenia requires a high degree of suspicion to avoid delay in initiation of treatment.",
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Pancytopenia in multiple myeloma-An Enigma : Our experience from tertiary care hospital. / Sridevi, Hanaganahalli B.; Rai, Sharada; Suresh, Pooja K.; Somesh, Meludurgamutt S.; Minal, Jessica.

In: Journal of Clinical and Diagnostic Research, Vol. 9, No. 11, 01.11.2015, p. EC04-EC06.

Research output: Contribution to journalArticle

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AB - Introduction: Multiple myeloma is a plasma cell neoplasm that is characterized by clonal proliferation of malignant plasma cell in the bone marrow along with M-protein in the serum and/or urine. Pancytopenia as a initial presentation of multiple myeloma is quite unusual. We are presenting a case series having pancytopenia as the presenting complaint. Materials and Methods: A retrospective study was conducted for a period of 30 months, wherein all the cases of multiple myeloma presenting with pancytopenia were included. The complete blood picture, peripheral smear examination, bone marrow aspirate & protein electrophoresis of all the cases were reviewed & analysed. Results: During the study period, 10 cases presented with pancytopenia with a mean age of 66.3 years (range: 59-72 years) at presentation with male: female ratio being 8:2. Fatigue and weakness was the most common symptom (100%) & average ESR was 104 mm/hour. High-resolution serum electrophoresis, showed a dense, sharp to wide M band in the gamma globulin region. Bone marrow plasma cell percentage was increased with an average of 63.1%. Bone marrow biopsy correlation was obtained in 100% cases. Conclusion: Diagnosing multiple myeloma, presenting as pancytopenia requires a high degree of suspicion to avoid delay in initiation of treatment.

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