Parameter optimization of a laser-induced fluorescence system for in vivo screening of oral cancer

V. K. Unnikrishnan; Rajesh Nayak; Rodney Bernard; K. Jeena Priya; Ajeetkumar Patil; J. Ebenezer; Keerthilatha M. Pai; Sajan D. George; V. B. Kartha; C. Santhosh

doi:10.2351/1.3591342

Parameter optimization of a laser-induced fluorescence system for in vivo screening of oral cancer

V. K. Unnikrishnan, Rajesh Nayak, Rodney Bernard, K. Jeena Priya, Ajeetkumar Patil, J. Ebenezer, Keerthilatha M. Pai, Sajan D. George, V. B. Kartha, C. Santhosh

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Despite the advances in optical technologies for early detection of cancer, routine clinical applications are still not standardized. Among several optical methods, laser-induced fluorescence is a more matured and well understood technique. Still due care has to be taken about various factors to avoid erroneous results. The authors have carried out a systematic study on the effect of the various experimental parameters such as source stability, area of exposure, and angular/distance dependence of a fiber probe, which is used for the fluorescence measurements, from the specimen surface on the spectra. Investigations are carried out on both idealistic cases as well as on tissue surface. The details of the optimization of the parameters are presented and discussed in this paper.

Original language	English
Article number	032004
Journal	Journal of Laser Applications
Volume	23
Issue number	3
DOIs	https://doi.org/10.2351/1.3591342
Publication status	Published - 01-08-2011

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomedical Engineering
Instrumentation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2351/1.3591342

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title = "Parameter optimization of a laser-induced fluorescence system for in vivo screening of oral cancer",

abstract = "Despite the advances in optical technologies for early detection of cancer, routine clinical applications are still not standardized. Among several optical methods, laser-induced fluorescence is a more matured and well understood technique. Still due care has to be taken about various factors to avoid erroneous results. The authors have carried out a systematic study on the effect of the various experimental parameters such as source stability, area of exposure, and angular/distance dependence of a fiber probe, which is used for the fluorescence measurements, from the specimen surface on the spectra. Investigations are carried out on both idealistic cases as well as on tissue surface. The details of the optimization of the parameters are presented and discussed in this paper.",

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AU - Unnikrishnan, V. K.

AU - Nayak, Rajesh

AU - Bernard, Rodney

AU - Priya, K. Jeena

AU - Patil, Ajeetkumar

AU - Ebenezer, J.

AU - Pai, Keerthilatha M.

AU - George, Sajan D.

AU - Kartha, V. B.

AU - Santhosh, C.

PY - 2011/8/1

Y1 - 2011/8/1

N2 - Despite the advances in optical technologies for early detection of cancer, routine clinical applications are still not standardized. Among several optical methods, laser-induced fluorescence is a more matured and well understood technique. Still due care has to be taken about various factors to avoid erroneous results. The authors have carried out a systematic study on the effect of the various experimental parameters such as source stability, area of exposure, and angular/distance dependence of a fiber probe, which is used for the fluorescence measurements, from the specimen surface on the spectra. Investigations are carried out on both idealistic cases as well as on tissue surface. The details of the optimization of the parameters are presented and discussed in this paper.

AB - Despite the advances in optical technologies for early detection of cancer, routine clinical applications are still not standardized. Among several optical methods, laser-induced fluorescence is a more matured and well understood technique. Still due care has to be taken about various factors to avoid erroneous results. The authors have carried out a systematic study on the effect of the various experimental parameters such as source stability, area of exposure, and angular/distance dependence of a fiber probe, which is used for the fluorescence measurements, from the specimen surface on the spectra. Investigations are carried out on both idealistic cases as well as on tissue surface. The details of the optimization of the parameters are presented and discussed in this paper.

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Parameter optimization of a laser-induced fluorescence system for in vivo screening of oral cancer

Abstract

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