Paraoxonase activity and antibodies to oxidized-LDL in chronic renal failure patients on renal replacement therapy

P. R. Krishnaswamy, Anjali Rao, W. Murali, H. Sudarshan Ballal

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Serum paraoxonase (PON1) and antibodies to oxidized-LDL (anti ox-LDL) were measured in chronic renal failure subjects on renal replacement therapy such as hemodialysis (HD) peritoneal dialysis (PD) and transplantation (Txp). Paraoxonase activity was significantly lower in HD and PD group (P<0.001) than in control subjects. In transplant patients, paraoxonase activity was not significantly different from that of controls. Antibodies to ox-LDL was significantly higher in HD, PD and Transplant patients (P<0.0001) compared to control subjects. High titers of antibodies were observed in the HD group compared to the PD and Transplant subjects. A decrease in paraoxonase activity and high titers of Antibodies to ox-LDL in the dialysis group suggest a decreased cardio protective effect of HDL and enhanced risk of premature cardiovascular complications. Whereas in case of transplant subjects, there seems to be restoration of PON1 activity, but elevated levels of anti-oxLDL could still be a potential atherogenic factor. Hence, we propose that estimation of these two parameters can be used as a useful index to measure the cardiac risk in the above patient category.

Original languageEnglish
Pages (from-to)173-176
Number of pages4
JournalIndian Journal of Clinical Biochemistry
Volume21
Issue number2
DOIs
Publication statusPublished - 21-11-2006

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Aryldialkylphosphatase
Renal Replacement Therapy
Dialysis
Peritoneal Dialysis
Transplants
Chronic Kidney Failure
Renal Dialysis
Antibodies
Transplantation
Restoration
low density lipoprotein inhibitor
oxidized low density lipoprotein
Serum

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Krishnaswamy, P. R. ; Rao, Anjali ; Murali, W. ; Ballal, H. Sudarshan. / Paraoxonase activity and antibodies to oxidized-LDL in chronic renal failure patients on renal replacement therapy. In: Indian Journal of Clinical Biochemistry. 2006 ; Vol. 21, No. 2. pp. 173-176.
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Paraoxonase activity and antibodies to oxidized-LDL in chronic renal failure patients on renal replacement therapy. / Krishnaswamy, P. R.; Rao, Anjali; Murali, W.; Ballal, H. Sudarshan.

In: Indian Journal of Clinical Biochemistry, Vol. 21, No. 2, 21.11.2006, p. 173-176.

Research output: Contribution to journalArticle

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