Paraoxonase activity in type 2 diabetes mellitus patients with and without complications

Renuka Suvarna, Soumya S. Rao, Chitralekha Joshi, Vivekananda Kedage, Manjunatha S. Muttigi, Jeevan K. Shetty, Mungli Prakash

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Introduction: Type 2 diabetes mellitus (DM) is a disease of metabolic dysregulation. The current study was undertaken to understand the relationship between the fasting lipid profile and the paraoxonase 1 (PON1) activity in type 2 diabetic patients, with and without complications. Materials and methods: The study group consisted of a total of 155 subjects, which included non-diabetic healthy control subjects (n = 50) and diabetic patients with complications (group I, n = 66) and without complications (group II, n=39). PON1 activity was measured in all the subjects, based on spectrophotometric methods and the fasting lipid profile and the fasting plasma glucose (FPG) levels were determined by using a clinical chemistry analyzer, Hitachi 912. Results: FPG (p<0.001) and triacylglycerides (TAG) (p<0.001) were significantly increased and high-density lipoprotein-cholesterol (HDL-C) (p<0.001) and PON1 (p<0.001) were significantly decreased in group I patients as compared to the normal controls. In group II patients, FPG (p<0.001), TAG (p<0.001) and total cholesterol (TC) (p<0.05) were significantly increased and HDL-C (p<0.05) was significantly decreased as compared to the normal controls. By using Pearson's correlation, HDL-C was found to be positively correlated with PON1 in group I patients (r=0.317, p<0.01).Conclusion: Type 2 DM patients with complications have significantly decreased HDL-C levels and PON1 activity, possibly indicating their decreased biochemical roles in these patients.

Original languageEnglish
Pages (from-to)63-65
Number of pages3
JournalJournal of Clinical and Diagnostic Research
Volume5
Issue number1
Publication statusPublished - 21-03-2011
Externally publishedYes

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Aryldialkylphosphatase
Medical problems
Type 2 Diabetes Mellitus
HDL Cholesterol
Fasting
Plasmas
Glucose
Lipids
Clinical Chemistry
Metabolic Diseases
Cholesterol
Healthy Volunteers

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Suvarna, R., Rao, S. S., Joshi, C., Kedage, V., Muttigi, M. S., Shetty, J. K., & Prakash, M. (2011). Paraoxonase activity in type 2 diabetes mellitus patients with and without complications. Journal of Clinical and Diagnostic Research, 5(1), 63-65.
Suvarna, Renuka ; Rao, Soumya S. ; Joshi, Chitralekha ; Kedage, Vivekananda ; Muttigi, Manjunatha S. ; Shetty, Jeevan K. ; Prakash, Mungli. / Paraoxonase activity in type 2 diabetes mellitus patients with and without complications. In: Journal of Clinical and Diagnostic Research. 2011 ; Vol. 5, No. 1. pp. 63-65.
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Suvarna, R, Rao, SS, Joshi, C, Kedage, V, Muttigi, MS, Shetty, JK & Prakash, M 2011, 'Paraoxonase activity in type 2 diabetes mellitus patients with and without complications', Journal of Clinical and Diagnostic Research, vol. 5, no. 1, pp. 63-65.

Paraoxonase activity in type 2 diabetes mellitus patients with and without complications. / Suvarna, Renuka; Rao, Soumya S.; Joshi, Chitralekha; Kedage, Vivekananda; Muttigi, Manjunatha S.; Shetty, Jeevan K.; Prakash, Mungli.

In: Journal of Clinical and Diagnostic Research, Vol. 5, No. 1, 21.03.2011, p. 63-65.

Research output: Contribution to journalArticle

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T1 - Paraoxonase activity in type 2 diabetes mellitus patients with and without complications

AU - Suvarna, Renuka

AU - Rao, Soumya S.

AU - Joshi, Chitralekha

AU - Kedage, Vivekananda

AU - Muttigi, Manjunatha S.

AU - Shetty, Jeevan K.

AU - Prakash, Mungli

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N2 - Introduction: Type 2 diabetes mellitus (DM) is a disease of metabolic dysregulation. The current study was undertaken to understand the relationship between the fasting lipid profile and the paraoxonase 1 (PON1) activity in type 2 diabetic patients, with and without complications. Materials and methods: The study group consisted of a total of 155 subjects, which included non-diabetic healthy control subjects (n = 50) and diabetic patients with complications (group I, n = 66) and without complications (group II, n=39). PON1 activity was measured in all the subjects, based on spectrophotometric methods and the fasting lipid profile and the fasting plasma glucose (FPG) levels were determined by using a clinical chemistry analyzer, Hitachi 912. Results: FPG (p<0.001) and triacylglycerides (TAG) (p<0.001) were significantly increased and high-density lipoprotein-cholesterol (HDL-C) (p<0.001) and PON1 (p<0.001) were significantly decreased in group I patients as compared to the normal controls. In group II patients, FPG (p<0.001), TAG (p<0.001) and total cholesterol (TC) (p<0.05) were significantly increased and HDL-C (p<0.05) was significantly decreased as compared to the normal controls. By using Pearson's correlation, HDL-C was found to be positively correlated with PON1 in group I patients (r=0.317, p<0.01).Conclusion: Type 2 DM patients with complications have significantly decreased HDL-C levels and PON1 activity, possibly indicating their decreased biochemical roles in these patients.

AB - Introduction: Type 2 diabetes mellitus (DM) is a disease of metabolic dysregulation. The current study was undertaken to understand the relationship between the fasting lipid profile and the paraoxonase 1 (PON1) activity in type 2 diabetic patients, with and without complications. Materials and methods: The study group consisted of a total of 155 subjects, which included non-diabetic healthy control subjects (n = 50) and diabetic patients with complications (group I, n = 66) and without complications (group II, n=39). PON1 activity was measured in all the subjects, based on spectrophotometric methods and the fasting lipid profile and the fasting plasma glucose (FPG) levels were determined by using a clinical chemistry analyzer, Hitachi 912. Results: FPG (p<0.001) and triacylglycerides (TAG) (p<0.001) were significantly increased and high-density lipoprotein-cholesterol (HDL-C) (p<0.001) and PON1 (p<0.001) were significantly decreased in group I patients as compared to the normal controls. In group II patients, FPG (p<0.001), TAG (p<0.001) and total cholesterol (TC) (p<0.05) were significantly increased and HDL-C (p<0.05) was significantly decreased as compared to the normal controls. By using Pearson's correlation, HDL-C was found to be positively correlated with PON1 in group I patients (r=0.317, p<0.01).Conclusion: Type 2 DM patients with complications have significantly decreased HDL-C levels and PON1 activity, possibly indicating their decreased biochemical roles in these patients.

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Suvarna R, Rao SS, Joshi C, Kedage V, Muttigi MS, Shetty JK et al. Paraoxonase activity in type 2 diabetes mellitus patients with and without complications. Journal of Clinical and Diagnostic Research. 2011 Mar 21;5(1):63-65.