Paraoxonase

Its antiatherogenic role in chronic renal failure

M. Prakash, N. M. Phani, R. Kavya, M. Supriya

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Paraoxonase (PON) is an aryldialkylphosphatase, which reversibly binds and hydrolyzes organophosphates. The PON family has three members (PON1, PON2 and PON3); they share structural properties and enzymatic activities. PON1 is shown to reside over high density lipoprotein (HDL) and has both antioxidant and antiatherogenic functions. Function of PON2 and PON3 are speculative and still under research. Several methodologies were developed over the years to determine the activity and mass of PON1, of which spectrophotometer-based methods using certain chemicals as substrate predominate. Several studies have shown decreased levels of PON1 in chronic renal failure (CRF) patients, particularly those on hemodialysis. The role of PON1 in development of cardiovascular disease has drawn considerable attention in recent years. Several authors have shown decreased levels of HDL and PON1 activity in CRF patients on hemodialysis and reported this to be a risk factor in the development of CVD. Enhancement or maintenance of the PON1 activity may prevent development of CVDs and its consequences in patients on hemodialysis.

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalIndian Journal of Nephrology
Volume20
Issue number1
DOIs
Publication statusPublished - 01-01-2010
Externally publishedYes

Fingerprint

Aryldialkylphosphatase
Chronic Kidney Failure
Renal Dialysis
HDL Lipoproteins
Organophosphates
Cardiovascular Diseases
Antioxidants
Maintenance
Research

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Prakash, M. ; Phani, N. M. ; Kavya, R. ; Supriya, M. / Paraoxonase : Its antiatherogenic role in chronic renal failure. In: Indian Journal of Nephrology. 2010 ; Vol. 20, No. 1. pp. 9-14.
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Paraoxonase : Its antiatherogenic role in chronic renal failure. / Prakash, M.; Phani, N. M.; Kavya, R.; Supriya, M.

In: Indian Journal of Nephrology, Vol. 20, No. 1, 01.01.2010, p. 9-14.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Paraoxonase

T2 - Its antiatherogenic role in chronic renal failure

AU - Prakash, M.

AU - Phani, N. M.

AU - Kavya, R.

AU - Supriya, M.

PY - 2010/1/1

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N2 - Paraoxonase (PON) is an aryldialkylphosphatase, which reversibly binds and hydrolyzes organophosphates. The PON family has three members (PON1, PON2 and PON3); they share structural properties and enzymatic activities. PON1 is shown to reside over high density lipoprotein (HDL) and has both antioxidant and antiatherogenic functions. Function of PON2 and PON3 are speculative and still under research. Several methodologies were developed over the years to determine the activity and mass of PON1, of which spectrophotometer-based methods using certain chemicals as substrate predominate. Several studies have shown decreased levels of PON1 in chronic renal failure (CRF) patients, particularly those on hemodialysis. The role of PON1 in development of cardiovascular disease has drawn considerable attention in recent years. Several authors have shown decreased levels of HDL and PON1 activity in CRF patients on hemodialysis and reported this to be a risk factor in the development of CVD. Enhancement or maintenance of the PON1 activity may prevent development of CVDs and its consequences in patients on hemodialysis.

AB - Paraoxonase (PON) is an aryldialkylphosphatase, which reversibly binds and hydrolyzes organophosphates. The PON family has three members (PON1, PON2 and PON3); they share structural properties and enzymatic activities. PON1 is shown to reside over high density lipoprotein (HDL) and has both antioxidant and antiatherogenic functions. Function of PON2 and PON3 are speculative and still under research. Several methodologies were developed over the years to determine the activity and mass of PON1, of which spectrophotometer-based methods using certain chemicals as substrate predominate. Several studies have shown decreased levels of PON1 in chronic renal failure (CRF) patients, particularly those on hemodialysis. The role of PON1 in development of cardiovascular disease has drawn considerable attention in recent years. Several authors have shown decreased levels of HDL and PON1 activity in CRF patients on hemodialysis and reported this to be a risk factor in the development of CVD. Enhancement or maintenance of the PON1 activity may prevent development of CVDs and its consequences in patients on hemodialysis.

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