Parkinson's disease and periodontitis – the missing link? A review

Tejaswani Kaur, Ashita Uppoor, Dilip Naik

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Objective: In this article an attempt has been made to postulate a possible link between Parkinson's disease and periodontal disease. Background: Various systemic diseases such as cardiac disease, diabetes, renal diseases, low birth weight and Alzheimer's disease have been proposed to be linked with periodontal disease on the basis of systemic inflammation. Parkinson's disease is a chronic progressive neurodegenerative disorder with multifactorial aetiology. Until now, periodontal disease and Parkinson's disease has been linked only on the basis of poor motor and cognitive control in Parkinson's patient which leads to poor oral health maintenance. Evidence now suggests that chronic neuroinflammation is consistently associated with the pathophysiology of Parkinson's disease. Also, recently, systemic inflammation has been suggested as one of the contributing factors for neurodegeneration. Material and methods: Dental and medical literature especially those dealing with neurosciences were selected which highlighted the link between systemic inflammation and infection. Results: So far there is no direct evidence implicating an effect of periodontitis in the pathogenesis of Parkinson's disease. To clarify this link, studies on population based case–control or cohort design are needed. This would be especially significant in the present era where there is paucity for preventive measures as far as a cognitive disorder such as Parkinson's disease is concerned. Conclusion: We cannot cure Parkinson's disease, but if in future this missing link is established, an attempt can be made to prevent it by tackling one of its possible contributors (periodontitis) for systemic inflammation by simple preventive oral hygiene measures.

Original languageEnglish
Pages (from-to)434-438
Number of pages5
JournalGerodontology
Volume33
Issue number4
DOIs
Publication statusPublished - 01-12-2016

Fingerprint

Periodontitis
Parkinson Disease
Periodontal Diseases
Inflammation
Dental Materials
Oral Hygiene
Oral Health
Low Birth Weight Infant
Neurosciences
Neurodegenerative Diseases
Heart Diseases
Alzheimer Disease
Kidney
Infection
Population

All Science Journal Classification (ASJC) codes

  • Dentistry(all)
  • Geriatrics and Gerontology

Cite this

@article{0107abc19f194280867475fd33cba303,
title = "Parkinson's disease and periodontitis – the missing link? A review",
abstract = "Objective: In this article an attempt has been made to postulate a possible link between Parkinson's disease and periodontal disease. Background: Various systemic diseases such as cardiac disease, diabetes, renal diseases, low birth weight and Alzheimer's disease have been proposed to be linked with periodontal disease on the basis of systemic inflammation. Parkinson's disease is a chronic progressive neurodegenerative disorder with multifactorial aetiology. Until now, periodontal disease and Parkinson's disease has been linked only on the basis of poor motor and cognitive control in Parkinson's patient which leads to poor oral health maintenance. Evidence now suggests that chronic neuroinflammation is consistently associated with the pathophysiology of Parkinson's disease. Also, recently, systemic inflammation has been suggested as one of the contributing factors for neurodegeneration. Material and methods: Dental and medical literature especially those dealing with neurosciences were selected which highlighted the link between systemic inflammation and infection. Results: So far there is no direct evidence implicating an effect of periodontitis in the pathogenesis of Parkinson's disease. To clarify this link, studies on population based case–control or cohort design are needed. This would be especially significant in the present era where there is paucity for preventive measures as far as a cognitive disorder such as Parkinson's disease is concerned. Conclusion: We cannot cure Parkinson's disease, but if in future this missing link is established, an attempt can be made to prevent it by tackling one of its possible contributors (periodontitis) for systemic inflammation by simple preventive oral hygiene measures.",
author = "Tejaswani Kaur and Ashita Uppoor and Dilip Naik",
year = "2016",
month = "12",
day = "1",
doi = "10.1111/ger.12188",
language = "English",
volume = "33",
pages = "434--438",
journal = "Gerodontology",
issn = "0734-0664",
publisher = "Blackwell Munksgaard",
number = "4",

}

Parkinson's disease and periodontitis – the missing link? A review. / Kaur, Tejaswani; Uppoor, Ashita; Naik, Dilip.

In: Gerodontology, Vol. 33, No. 4, 01.12.2016, p. 434-438.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Parkinson's disease and periodontitis – the missing link? A review

AU - Kaur, Tejaswani

AU - Uppoor, Ashita

AU - Naik, Dilip

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Objective: In this article an attempt has been made to postulate a possible link between Parkinson's disease and periodontal disease. Background: Various systemic diseases such as cardiac disease, diabetes, renal diseases, low birth weight and Alzheimer's disease have been proposed to be linked with periodontal disease on the basis of systemic inflammation. Parkinson's disease is a chronic progressive neurodegenerative disorder with multifactorial aetiology. Until now, periodontal disease and Parkinson's disease has been linked only on the basis of poor motor and cognitive control in Parkinson's patient which leads to poor oral health maintenance. Evidence now suggests that chronic neuroinflammation is consistently associated with the pathophysiology of Parkinson's disease. Also, recently, systemic inflammation has been suggested as one of the contributing factors for neurodegeneration. Material and methods: Dental and medical literature especially those dealing with neurosciences were selected which highlighted the link between systemic inflammation and infection. Results: So far there is no direct evidence implicating an effect of periodontitis in the pathogenesis of Parkinson's disease. To clarify this link, studies on population based case–control or cohort design are needed. This would be especially significant in the present era where there is paucity for preventive measures as far as a cognitive disorder such as Parkinson's disease is concerned. Conclusion: We cannot cure Parkinson's disease, but if in future this missing link is established, an attempt can be made to prevent it by tackling one of its possible contributors (periodontitis) for systemic inflammation by simple preventive oral hygiene measures.

AB - Objective: In this article an attempt has been made to postulate a possible link between Parkinson's disease and periodontal disease. Background: Various systemic diseases such as cardiac disease, diabetes, renal diseases, low birth weight and Alzheimer's disease have been proposed to be linked with periodontal disease on the basis of systemic inflammation. Parkinson's disease is a chronic progressive neurodegenerative disorder with multifactorial aetiology. Until now, periodontal disease and Parkinson's disease has been linked only on the basis of poor motor and cognitive control in Parkinson's patient which leads to poor oral health maintenance. Evidence now suggests that chronic neuroinflammation is consistently associated with the pathophysiology of Parkinson's disease. Also, recently, systemic inflammation has been suggested as one of the contributing factors for neurodegeneration. Material and methods: Dental and medical literature especially those dealing with neurosciences were selected which highlighted the link between systemic inflammation and infection. Results: So far there is no direct evidence implicating an effect of periodontitis in the pathogenesis of Parkinson's disease. To clarify this link, studies on population based case–control or cohort design are needed. This would be especially significant in the present era where there is paucity for preventive measures as far as a cognitive disorder such as Parkinson's disease is concerned. Conclusion: We cannot cure Parkinson's disease, but if in future this missing link is established, an attempt can be made to prevent it by tackling one of its possible contributors (periodontitis) for systemic inflammation by simple preventive oral hygiene measures.

UR - http://www.scopus.com/inward/record.url?scp=84922495828&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922495828&partnerID=8YFLogxK

U2 - 10.1111/ger.12188

DO - 10.1111/ger.12188

M3 - Review article

C2 - 25664991

AN - SCOPUS:84922495828

VL - 33

SP - 434

EP - 438

JO - Gerodontology

JF - Gerodontology

SN - 0734-0664

IS - 4

ER -