Paroxetine useful for palmar-plantar hyperhidrosis

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19 Citations (Scopus)


OBJECTIVE: To report a case of palmar-plantar hyperhidrosis (PPH) in which paroxetine was found to be helpful. CASE SUMMARY: A 32-year-old man with a history of excessive sweating of the palms and soles since childhood was diagnosed with PPH and was prescribed paroxetine 10 mg/day, which was increased to 20 mg/day. After one month, he experienced a marked reduction in sweating and improvement in socio-occupational functioning, which were sustained during follow-up at 6 months without any emergent adverse effects. DISCUSSION: Paroxetine's anticholinergic action may be responsible for its beneficial effect in PPH, as it may override the adrenergic mechanism, which has a minor effect on sweating from eccrine glands. Alternatively, paroxetine's beneficial effect in PPH may be secondary to its antianxiety effect, through central mechanisms. CONCLUSIONS: Paroxetine may be a useful option in the treatment of PPH.

Original languageEnglish
Pages (from-to)1884-1886
Number of pages3
JournalAnnals of Pharmacotherapy
Issue number10
Publication statusPublished - 01-10-2006

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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