Abstract
Guillain-Barré syndrome (GBS) is an autoimmune polyneuropathy which presents with acute onset and rapid progression of flaccid, hyporeflexi quadriparesis. Both sensory and autonomic nerve involvement is seen. GBS has various subtypes that vary in their pathophysiology. The pathogenesis involves an immune response triggered by a preceding event which may be an infection, immunisation or surgical procedure. Clinical diagnosis has been largely the primary diagnosing criterion for GBS along with electrodiagnosis, which has several pitfalls and is supported by ancillary testing of cerebrospinal fluid (CSF) analysis and Nerve Conduction Studies. Measurement of anti-ganglioside antibodies is also an effective tool in its diagnosis. Further understanding of pathophysiology and better diagnostic methods are required for better management of GBS.
| Original language | English |
|---|---|
| Pages (from-to) | 235-240 |
| Number of pages | 6 |
| Journal | International Journal of Neuroscience |
| Volume | 125 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 01-06-2015 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Neuroscience(all)
Cite this
}
Pathophysiology and diagnosis of Guillain-Barré syndrome-challenges and needs. / Dash, Sambit; Pai, Aparna R.; Kamath, Ullas; Rao, Pragna.
In: International Journal of Neuroscience, Vol. 125, No. 4, 01.06.2015, p. 235-240.Research output: Contribution to journal › Article
TY - JOUR
T1 - Pathophysiology and diagnosis of Guillain-Barré syndrome-challenges and needs
AU - Dash, Sambit
AU - Pai, Aparna R.
AU - Kamath, Ullas
AU - Rao, Pragna
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Guillain-Barré syndrome (GBS) is an autoimmune polyneuropathy which presents with acute onset and rapid progression of flaccid, hyporeflexi quadriparesis. Both sensory and autonomic nerve involvement is seen. GBS has various subtypes that vary in their pathophysiology. The pathogenesis involves an immune response triggered by a preceding event which may be an infection, immunisation or surgical procedure. Clinical diagnosis has been largely the primary diagnosing criterion for GBS along with electrodiagnosis, which has several pitfalls and is supported by ancillary testing of cerebrospinal fluid (CSF) analysis and Nerve Conduction Studies. Measurement of anti-ganglioside antibodies is also an effective tool in its diagnosis. Further understanding of pathophysiology and better diagnostic methods are required for better management of GBS.
AB - Guillain-Barré syndrome (GBS) is an autoimmune polyneuropathy which presents with acute onset and rapid progression of flaccid, hyporeflexi quadriparesis. Both sensory and autonomic nerve involvement is seen. GBS has various subtypes that vary in their pathophysiology. The pathogenesis involves an immune response triggered by a preceding event which may be an infection, immunisation or surgical procedure. Clinical diagnosis has been largely the primary diagnosing criterion for GBS along with electrodiagnosis, which has several pitfalls and is supported by ancillary testing of cerebrospinal fluid (CSF) analysis and Nerve Conduction Studies. Measurement of anti-ganglioside antibodies is also an effective tool in its diagnosis. Further understanding of pathophysiology and better diagnostic methods are required for better management of GBS.
UR - http://www.scopus.com/inward/record.url?scp=84931065612&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84931065612&partnerID=8YFLogxK
U2 - 10.3109/00207454.2014.913588
DO - 10.3109/00207454.2014.913588
M3 - Article
C2 - 24731000
AN - SCOPUS:84931065612
VL - 125
SP - 235
EP - 240
JO - International Journal of Neuroscience
JF - International Journal of Neuroscience
SN - 0020-7454
IS - 4
ER -