Abstract

Guillain-Barré syndrome (GBS) is an autoimmune polyneuropathy which presents with acute onset and rapid progression of flaccid, hyporeflexi quadriparesis. Both sensory and autonomic nerve involvement is seen. GBS has various subtypes that vary in their pathophysiology. The pathogenesis involves an immune response triggered by a preceding event which may be an infection, immunisation or surgical procedure. Clinical diagnosis has been largely the primary diagnosing criterion for GBS along with electrodiagnosis, which has several pitfalls and is supported by ancillary testing of cerebrospinal fluid (CSF) analysis and Nerve Conduction Studies. Measurement of anti-ganglioside antibodies is also an effective tool in its diagnosis. Further understanding of pathophysiology and better diagnostic methods are required for better management of GBS.

Original languageEnglish
Pages (from-to)235-240
Number of pages6
JournalInternational Journal of Neuroscience
Volume125
Issue number4
DOIs
Publication statusPublished - 01-06-2015

Fingerprint

Electrodiagnosis
Autonomic Pathways
Quadriplegia
Polyneuropathies
Gangliosides
Neural Conduction
Cerebrospinal Fluid
Anti-Idiotypic Antibodies
Immunization
Infection

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

@article{9a2a7e82c6a8471c984f39ba80e88405,
title = "Pathophysiology and diagnosis of Guillain-Barr{\'e} syndrome-challenges and needs",
abstract = "Guillain-Barr{\'e} syndrome (GBS) is an autoimmune polyneuropathy which presents with acute onset and rapid progression of flaccid, hyporeflexi quadriparesis. Both sensory and autonomic nerve involvement is seen. GBS has various subtypes that vary in their pathophysiology. The pathogenesis involves an immune response triggered by a preceding event which may be an infection, immunisation or surgical procedure. Clinical diagnosis has been largely the primary diagnosing criterion for GBS along with electrodiagnosis, which has several pitfalls and is supported by ancillary testing of cerebrospinal fluid (CSF) analysis and Nerve Conduction Studies. Measurement of anti-ganglioside antibodies is also an effective tool in its diagnosis. Further understanding of pathophysiology and better diagnostic methods are required for better management of GBS.",
author = "Sambit Dash and Pai, {Aparna R.} and Ullas Kamath and Pragna Rao",
year = "2015",
month = "6",
day = "1",
doi = "10.3109/00207454.2014.913588",
language = "English",
volume = "125",
pages = "235--240",
journal = "International Journal of Neuroscience",
issn = "0020-7454",
publisher = "Informa Healthcare",
number = "4",

}

Pathophysiology and diagnosis of Guillain-Barré syndrome-challenges and needs. / Dash, Sambit; Pai, Aparna R.; Kamath, Ullas; Rao, Pragna.

In: International Journal of Neuroscience, Vol. 125, No. 4, 01.06.2015, p. 235-240.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pathophysiology and diagnosis of Guillain-Barré syndrome-challenges and needs

AU - Dash, Sambit

AU - Pai, Aparna R.

AU - Kamath, Ullas

AU - Rao, Pragna

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Guillain-Barré syndrome (GBS) is an autoimmune polyneuropathy which presents with acute onset and rapid progression of flaccid, hyporeflexi quadriparesis. Both sensory and autonomic nerve involvement is seen. GBS has various subtypes that vary in their pathophysiology. The pathogenesis involves an immune response triggered by a preceding event which may be an infection, immunisation or surgical procedure. Clinical diagnosis has been largely the primary diagnosing criterion for GBS along with electrodiagnosis, which has several pitfalls and is supported by ancillary testing of cerebrospinal fluid (CSF) analysis and Nerve Conduction Studies. Measurement of anti-ganglioside antibodies is also an effective tool in its diagnosis. Further understanding of pathophysiology and better diagnostic methods are required for better management of GBS.

AB - Guillain-Barré syndrome (GBS) is an autoimmune polyneuropathy which presents with acute onset and rapid progression of flaccid, hyporeflexi quadriparesis. Both sensory and autonomic nerve involvement is seen. GBS has various subtypes that vary in their pathophysiology. The pathogenesis involves an immune response triggered by a preceding event which may be an infection, immunisation or surgical procedure. Clinical diagnosis has been largely the primary diagnosing criterion for GBS along with electrodiagnosis, which has several pitfalls and is supported by ancillary testing of cerebrospinal fluid (CSF) analysis and Nerve Conduction Studies. Measurement of anti-ganglioside antibodies is also an effective tool in its diagnosis. Further understanding of pathophysiology and better diagnostic methods are required for better management of GBS.

UR - http://www.scopus.com/inward/record.url?scp=84931065612&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84931065612&partnerID=8YFLogxK

U2 - 10.3109/00207454.2014.913588

DO - 10.3109/00207454.2014.913588

M3 - Article

VL - 125

SP - 235

EP - 240

JO - International Journal of Neuroscience

JF - International Journal of Neuroscience

SN - 0020-7454

IS - 4

ER -