Patterns of granulomatous responses in TB lymphadenitis and their correlation with treatment outcomes

Debarshi Saha, Komal Rautela, Ashwani Kumar, Pooja K. Suresh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction Four patterns are noted in aspirates of TB lymphadenitis with or without concomitant HIV. They are granulomatous, necrotizing granulomatous, predominantly necrotizing and necrotizing suppurative designated pattern 1, 2, 3 and 4, respectively. The present study attempted to correlate granulomatous patterns, Acid Fast Bacilli (AFB) density with treatment outcomes. Materials and methods The MGG and Papanicolaou stained slides of 56 lymphadenitis patients, 38 TB and 18 TB with seropositive HIV were studied for two years. The AFB were stratified into: 0 – nil (1 – ≤1 AFB, 2 – >1 but <10 AFB, 3 – ≥10 AFB)/10 fields. Results There were 35 males and 21 females. Eleven aspirates demonstrated AFB. TB+HIV lymphadenitis displayed a higher AFB score. TB+HIV lymphadenitis aspirates significantly showed higher grade granulomas and AFB. TB+HIV lymphadenitis required ≥8-month treatment. Granulomas (pattern 3 or 4) but not high AFB scores required longer treatment (>6 months). Treatment of AFB (≥1) often extended to >6 months. Conclusion TB with seropositive HIV, possibly due to defective immune regulation exhibited granulomas (pattern 3 or 4) necessitating treatment for ≥8 months. Pattern 3 or 4 granulomas irrespective of HIV status demanded >6-month treatment.

Original languageEnglish
Pages (from-to)171-175
Number of pages5
JournalIndian Journal of Tuberculosis
Volume63
Issue number3
DOIs
Publication statusPublished - 01-07-2016

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Lymphadenitis
Bacillus
HIV
Acids
Granuloma
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Infectious Diseases

Cite this

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title = "Patterns of granulomatous responses in TB lymphadenitis and their correlation with treatment outcomes",
abstract = "Introduction Four patterns are noted in aspirates of TB lymphadenitis with or without concomitant HIV. They are granulomatous, necrotizing granulomatous, predominantly necrotizing and necrotizing suppurative designated pattern 1, 2, 3 and 4, respectively. The present study attempted to correlate granulomatous patterns, Acid Fast Bacilli (AFB) density with treatment outcomes. Materials and methods The MGG and Papanicolaou stained slides of 56 lymphadenitis patients, 38 TB and 18 TB with seropositive HIV were studied for two years. The AFB were stratified into: 0 – nil (1 – ≤1 AFB, 2 – >1 but <10 AFB, 3 – ≥10 AFB)/10 fields. Results There were 35 males and 21 females. Eleven aspirates demonstrated AFB. TB+HIV lymphadenitis displayed a higher AFB score. TB+HIV lymphadenitis aspirates significantly showed higher grade granulomas and AFB. TB+HIV lymphadenitis required ≥8-month treatment. Granulomas (pattern 3 or 4) but not high AFB scores required longer treatment (>6 months). Treatment of AFB (≥1) often extended to >6 months. Conclusion TB with seropositive HIV, possibly due to defective immune regulation exhibited granulomas (pattern 3 or 4) necessitating treatment for ≥8 months. Pattern 3 or 4 granulomas irrespective of HIV status demanded >6-month treatment.",
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Patterns of granulomatous responses in TB lymphadenitis and their correlation with treatment outcomes. / Saha, Debarshi; Rautela, Komal; Kumar, Ashwani; Suresh, Pooja K.

In: Indian Journal of Tuberculosis, Vol. 63, No. 3, 01.07.2016, p. 171-175.

Research output: Contribution to journalArticle

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