Periampullary carcinoma

An audit of an institutional experience with literature review

Bala Ram Malla, Gabriel Rodrigues

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Background: Periampullary carcinoma constitutes a distinct entity as compared to the classical pancreatic head cancer. Diagnosis, management and prognosis have improved considerably in the last few decades. The present study looks into the modes of presen-tation in patients with periampullary carcinoma, the different modalities of investigations, treatment along with the postoperative morbidity and mortality. Material and Methods: A retrospective and prospective observational study was done at Kasturba Medical College, Manipal Universi-ty, India between January 2007 and December 2009 and patients diagnosed to have periampullary carcinoma were included. Results: A total of 48 patients were studied, out of which, majority, i.e., 26 (54.16%) had carcinoma head of pancreas. Eight (16.66%) patients had carcinoma of duodenum and eight (16.66%), carcinoma of ampulla of Vater. Thirteen (27.08%) patients with resectable tumors underwent pancreatoduodenectomy (Whipple's operation) while remaining 13 (27.08%) underwent palliative bypass sur-gery. Post Whipple's operation mortality was less than 10%. Conclusions: Periampullary cancers vary in outcome after potentially curative resections that are well standardized. Tumor biology may play a crucial role in these differences.

Original languageEnglish
Pages (from-to)4-6
Number of pages3
JournalSurgical Chronicles
Volume22
Issue number1
Publication statusPublished - 01-01-2017

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Carcinoma
Ampulla of Vater
Neoplasms
Pancreaticoduodenectomy
Mortality
Head and Neck Neoplasms
Pancreatic Neoplasms
Duodenum
Observational Studies
India
Pancreas
Prospective Studies
Morbidity
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

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title = "Periampullary carcinoma: An audit of an institutional experience with literature review",
abstract = "Background: Periampullary carcinoma constitutes a distinct entity as compared to the classical pancreatic head cancer. Diagnosis, management and prognosis have improved considerably in the last few decades. The present study looks into the modes of presen-tation in patients with periampullary carcinoma, the different modalities of investigations, treatment along with the postoperative morbidity and mortality. Material and Methods: A retrospective and prospective observational study was done at Kasturba Medical College, Manipal Universi-ty, India between January 2007 and December 2009 and patients diagnosed to have periampullary carcinoma were included. Results: A total of 48 patients were studied, out of which, majority, i.e., 26 (54.16{\%}) had carcinoma head of pancreas. Eight (16.66{\%}) patients had carcinoma of duodenum and eight (16.66{\%}), carcinoma of ampulla of Vater. Thirteen (27.08{\%}) patients with resectable tumors underwent pancreatoduodenectomy (Whipple's operation) while remaining 13 (27.08{\%}) underwent palliative bypass sur-gery. Post Whipple's operation mortality was less than 10{\%}. Conclusions: Periampullary cancers vary in outcome after potentially curative resections that are well standardized. Tumor biology may play a crucial role in these differences.",
author = "Malla, {Bala Ram} and Gabriel Rodrigues",
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Periampullary carcinoma : An audit of an institutional experience with literature review. / Malla, Bala Ram; Rodrigues, Gabriel.

In: Surgical Chronicles, Vol. 22, No. 1, 01.01.2017, p. 4-6.

Research output: Contribution to journalReview article

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T2 - An audit of an institutional experience with literature review

AU - Malla, Bala Ram

AU - Rodrigues, Gabriel

PY - 2017/1/1

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N2 - Background: Periampullary carcinoma constitutes a distinct entity as compared to the classical pancreatic head cancer. Diagnosis, management and prognosis have improved considerably in the last few decades. The present study looks into the modes of presen-tation in patients with periampullary carcinoma, the different modalities of investigations, treatment along with the postoperative morbidity and mortality. Material and Methods: A retrospective and prospective observational study was done at Kasturba Medical College, Manipal Universi-ty, India between January 2007 and December 2009 and patients diagnosed to have periampullary carcinoma were included. Results: A total of 48 patients were studied, out of which, majority, i.e., 26 (54.16%) had carcinoma head of pancreas. Eight (16.66%) patients had carcinoma of duodenum and eight (16.66%), carcinoma of ampulla of Vater. Thirteen (27.08%) patients with resectable tumors underwent pancreatoduodenectomy (Whipple's operation) while remaining 13 (27.08%) underwent palliative bypass sur-gery. Post Whipple's operation mortality was less than 10%. Conclusions: Periampullary cancers vary in outcome after potentially curative resections that are well standardized. Tumor biology may play a crucial role in these differences.

AB - Background: Periampullary carcinoma constitutes a distinct entity as compared to the classical pancreatic head cancer. Diagnosis, management and prognosis have improved considerably in the last few decades. The present study looks into the modes of presen-tation in patients with periampullary carcinoma, the different modalities of investigations, treatment along with the postoperative morbidity and mortality. Material and Methods: A retrospective and prospective observational study was done at Kasturba Medical College, Manipal Universi-ty, India between January 2007 and December 2009 and patients diagnosed to have periampullary carcinoma were included. Results: A total of 48 patients were studied, out of which, majority, i.e., 26 (54.16%) had carcinoma head of pancreas. Eight (16.66%) patients had carcinoma of duodenum and eight (16.66%), carcinoma of ampulla of Vater. Thirteen (27.08%) patients with resectable tumors underwent pancreatoduodenectomy (Whipple's operation) while remaining 13 (27.08%) underwent palliative bypass sur-gery. Post Whipple's operation mortality was less than 10%. Conclusions: Periampullary cancers vary in outcome after potentially curative resections that are well standardized. Tumor biology may play a crucial role in these differences.

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