Perinatal human immunodeficiency virus infection

Avinash K. Shetty, Yvonne A. Maldonado

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Introduction Since the initial description of acquired immune deficiency syndrome (AIDS) cases in infants and children more than 25 years ago, the epidemiology of the pediatric human immunodeficiency virus type 1 (HIV-1) epidemic has changed significantly. Most pediatric HIV infections occur through perinatal transmission. Dramatic declines in the number of perinatally HIV infected children have been reported in the USA and Europe due to prompt implementation of strategies to prevent mother-to-child transmission of HIV (PMTCT). Further, availability of highly active antiretroviral therapy (HAART) has led to improved survival of HIV-infected children into adolescence and adulthood, changing most HIV infections into a chronic rather than an acute disease. In contrast, prevention of mother-to-child HIV transmission is a major public health challenge in many resource-limited countries. Although several effective, simple, and less expensive prophylactic antiretroviral regimens are available to prevent perinatal HIV transmission, these interventions have not been widely implemented in the developing world. Pediatricians and obstetricians play a crucial role in the prevention of perinatal HIV transmission, including identification of HIV-infected women during pregnancy, treatment of the pregnant women with appropriate antiretroviral therapy, ensuring evaluation for HIV infection in early infancy, and subsequent provision of ongoing care for children and families affected by HIV. The purpose of this chapter is to review advances in the prevention of perinatal HIV transmission and highlight certain unique features of HIV infection in infants with a focus on early diagnosis, clinical manifestations, treatment, and prognosis.

Original languageEnglish
Title of host publicationFetal and Neonatal Brain Injury, Fourth Edition
PublisherCambridge University Press
Pages378-388
Number of pages11
ISBN (Electronic)9780511581281
ISBN (Print)9780521888592
DOIs
Publication statusPublished - 01-01-2009
Externally publishedYes

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Virus Diseases
HIV
HIV Infections
Mothers
Pediatrics
Highly Active Antiretroviral Therapy
Acute Disease
Child Care
HIV-1
Pregnant Women
Early Diagnosis
Acquired Immunodeficiency Syndrome
Epidemiology
Therapeutics
Public Health
Pregnancy
Survival

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Shetty, A. K., & Maldonado, Y. A. (2009). Perinatal human immunodeficiency virus infection. In Fetal and Neonatal Brain Injury, Fourth Edition (pp. 378-388). Cambridge University Press. https://doi.org/10.1017/CBO9780511581281.035
Shetty, Avinash K. ; Maldonado, Yvonne A. / Perinatal human immunodeficiency virus infection. Fetal and Neonatal Brain Injury, Fourth Edition. Cambridge University Press, 2009. pp. 378-388
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Shetty, AK & Maldonado, YA 2009, Perinatal human immunodeficiency virus infection. in Fetal and Neonatal Brain Injury, Fourth Edition. Cambridge University Press, pp. 378-388. https://doi.org/10.1017/CBO9780511581281.035

Perinatal human immunodeficiency virus infection. / Shetty, Avinash K.; Maldonado, Yvonne A.

Fetal and Neonatal Brain Injury, Fourth Edition. Cambridge University Press, 2009. p. 378-388.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Shetty AK, Maldonado YA. Perinatal human immunodeficiency virus infection. In Fetal and Neonatal Brain Injury, Fourth Edition. Cambridge University Press. 2009. p. 378-388 https://doi.org/10.1017/CBO9780511581281.035