Periodontal disease and hemolysis in glucose-6-phosphate dehydrogenase deficiency: Is there a nexus?

Neelesh Singh; Ashita Uppoor; Valliammai Rajendran; Dilip G. Naik

doi:10.1016/j.job.2019.03.001

Periodontal disease and hemolysis in glucose-6-phosphate dehydrogenase deficiency: Is there a nexus?

Neelesh Singh, Ashita Uppoor, Valliammai Rajendran, Dilip G. Naik

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an erythrocyte enzyme defect that amplifies the susceptibility of erythrocytes to oxidative stress due to excessive levels of reactive oxygen species. Consequently, erythrocyte destruction and hemolysis occur. Highlight: The possible mechanism of oxidative stress-mediated destruction of erythrocytes in G6PD deficient individuals induced by periodontal infection is highlighted. Conclusion: Periodontal diseases feature systemic loading of reactive oxygen species, and they may increase the risk of hemolysis in individuals with G6PD deficiency.

Original language	English
Pages (from-to)	129-133
Number of pages	5
Journal	Journal of Oral Biosciences
Volume	61
Issue number	2
DOIs	https://doi.org/10.1016/j.job.2019.03.001
Publication status	Published - 01-06-2019

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Dentistry(all)
Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.job.2019.03.001

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title = "Periodontal disease and hemolysis in glucose-6-phosphate dehydrogenase deficiency: Is there a nexus?",

abstract = "Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an erythrocyte enzyme defect that amplifies the susceptibility of erythrocytes to oxidative stress due to excessive levels of reactive oxygen species. Consequently, erythrocyte destruction and hemolysis occur. Highlight: The possible mechanism of oxidative stress-mediated destruction of erythrocytes in G6PD deficient individuals induced by periodontal infection is highlighted. Conclusion: Periodontal diseases feature systemic loading of reactive oxygen species, and they may increase the risk of hemolysis in individuals with G6PD deficiency.",

author = "Neelesh Singh and Ashita Uppoor and Valliammai Rajendran and Naik, {Dilip G.}",

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AU - Uppoor, Ashita

AU - Rajendran, Valliammai

AU - Naik, Dilip G.

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an erythrocyte enzyme defect that amplifies the susceptibility of erythrocytes to oxidative stress due to excessive levels of reactive oxygen species. Consequently, erythrocyte destruction and hemolysis occur. Highlight: The possible mechanism of oxidative stress-mediated destruction of erythrocytes in G6PD deficient individuals induced by periodontal infection is highlighted. Conclusion: Periodontal diseases feature systemic loading of reactive oxygen species, and they may increase the risk of hemolysis in individuals with G6PD deficiency.

AB - Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an erythrocyte enzyme defect that amplifies the susceptibility of erythrocytes to oxidative stress due to excessive levels of reactive oxygen species. Consequently, erythrocyte destruction and hemolysis occur. Highlight: The possible mechanism of oxidative stress-mediated destruction of erythrocytes in G6PD deficient individuals induced by periodontal infection is highlighted. Conclusion: Periodontal diseases feature systemic loading of reactive oxygen species, and they may increase the risk of hemolysis in individuals with G6PD deficiency.

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Periodontal disease and hemolysis in glucose-6-phosphate dehydrogenase deficiency: Is there a nexus?

Abstract

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