Periodontal disease and hemolysis in glucose-6-phosphate dehydrogenase deficiency

Is there a nexus?

Neelesh Singh, Ashita Uppoor, Valliammai Rajendran, Dilip G. Naik

Research output: Contribution to journalArticle

Abstract

Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an erythrocyte enzyme defect that amplifies the susceptibility of erythrocytes to oxidative stress due to excessive levels of reactive oxygen species. Consequently, erythrocyte destruction and hemolysis occur. Highlight: The possible mechanism of oxidative stress-mediated destruction of erythrocytes in G6PD deficient individuals induced by periodontal infection is highlighted. Conclusion: Periodontal diseases feature systemic loading of reactive oxygen species, and they may increase the risk of hemolysis in individuals with G6PD deficiency.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalJournal of Oral Biosciences
Volume61
Issue number2
DOIs
Publication statusPublished - 01-06-2019

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Glucosephosphate Dehydrogenase Deficiency
Glucosephosphate Dehydrogenase
Periodontal Diseases
Hemolysis
Oxidative stress
Erythrocytes
Reactive Oxygen Species
Oxidative Stress
Defects
Enzymes
Nexus
Infection

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Dentistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Periodontal disease and hemolysis in glucose-6-phosphate dehydrogenase deficiency: Is there a nexus?",
abstract = "Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an erythrocyte enzyme defect that amplifies the susceptibility of erythrocytes to oxidative stress due to excessive levels of reactive oxygen species. Consequently, erythrocyte destruction and hemolysis occur. Highlight: The possible mechanism of oxidative stress-mediated destruction of erythrocytes in G6PD deficient individuals induced by periodontal infection is highlighted. Conclusion: Periodontal diseases feature systemic loading of reactive oxygen species, and they may increase the risk of hemolysis in individuals with G6PD deficiency.",
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Periodontal disease and hemolysis in glucose-6-phosphate dehydrogenase deficiency : Is there a nexus? / Singh, Neelesh; Uppoor, Ashita; Rajendran, Valliammai; Naik, Dilip G.

In: Journal of Oral Biosciences, Vol. 61, No. 2, 01.06.2019, p. 129-133.

Research output: Contribution to journalArticle

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T1 - Periodontal disease and hemolysis in glucose-6-phosphate dehydrogenase deficiency

T2 - Is there a nexus?

AU - Singh, Neelesh

AU - Uppoor, Ashita

AU - Rajendran, Valliammai

AU - Naik, Dilip G.

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