Pharmacodynamic and pharmacokinetic profiles of diclofenac topical preparations

C. Jayanthi, N. Udupa

Research output: Contribution to journalArticle

Abstract

An aqueous cream formulation of diclofenac sodium, exhibiting maximum permeation flux across freshly excised mouse skin was evaluated for anti- inflammatory activity, using carrangeenan-induced paw oedema and cotton pellet-induced granuloma models in rats and found to be as effective as the marketed gel and oral administration at the equivalent dose of 25 mg/kg body weight. Similar plasma concentration profiles were observed for both formulated and marketed gels. Despite the lower bioavailability (about 2.5 times) compared to the oral route, the effective therapeutic levels were sustained over 24 hours following single transdermal application in rats.

Original languageEnglish
Pages (from-to)606-610
Number of pages5
JournalIndian Drugs
Volume30
Issue number12
Publication statusPublished - 1993

Fingerprint

Diclofenac
Pharmacokinetics
Gels
Granuloma
Biological Availability
Oral Administration
Edema
Anti-Inflammatory Agents
Body Weight
Skin
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

Cite this

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Pharmacodynamic and pharmacokinetic profiles of diclofenac topical preparations. / Jayanthi, C.; Udupa, N.

In: Indian Drugs, Vol. 30, No. 12, 1993, p. 606-610.

Research output: Contribution to journalArticle

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