Pharmacognostical standardisation and cytotoxicity screening of Bridelia retusa spreng

Seena Kanniparambil Xavier, Praveen Kallamvalliillam Sankaran, Devkar Raviraj Ananad, Chandrasekhara Shastry Shreedhara, Manganahally Manjunath Setty

Research output: Contribution to journalArticle

Abstract

Bridelia retusa is an indigenous medicinal plants belonging to family Euphorbiaceae and are used in the treatment of various disorders such as inflammation, kidney stones, urinary disorders, diarrhoea and dysentery. The stem bark of Bridelia retusa was subjected for macro and microscopical analysis, various physico chemical standardisation parameters and phytochemical studies according to Indian Pharmacopoeia. Total phenolic and flavonoid content were estimated using standard procedures. Cytotoxicity screening of methanol extract of Bridelia retusa was performed in Vero cells by sulforhodamine assay. The present study provides standardisation parameters for Bridelia retusa which will aid in the proper identification and authentication of the plant. Further, results of cytotoxicity screening revealed that plant exhibits no toxicity even at higher concentration and IC50 was found to be 430.6 μg/ml.

Original languageEnglish
Pages (from-to)1773-1776
Number of pages4
JournalAdvanced Science Letters
Volume23
Issue number3
DOIs
Publication statusPublished - 01-03-2017

Fingerprint

Cytotoxicity
Standardization
standardization
Screening
Disorder
dysentery
Flavonoids
Inflammation
medicinal plant
Kidney
Toxicity
Authentication
Euphorbiaceae
bark
Macros
methanol
Assays
Dysentery
Pharmacopoeias
Vero Cells

All Science Journal Classification (ASJC) codes

  • Health(social science)
  • Computer Science(all)
  • Education
  • Mathematics(all)
  • Environmental Science(all)
  • Engineering(all)
  • Energy(all)

Cite this

Xavier, Seena Kanniparambil ; Sankaran, Praveen Kallamvalliillam ; Ananad, Devkar Raviraj ; Shreedhara, Chandrasekhara Shastry ; Setty, Manganahally Manjunath. / Pharmacognostical standardisation and cytotoxicity screening of Bridelia retusa spreng. In: Advanced Science Letters. 2017 ; Vol. 23, No. 3. pp. 1773-1776.
@article{79ac429f91934743a412ed38ec759680,
title = "Pharmacognostical standardisation and cytotoxicity screening of Bridelia retusa spreng",
abstract = "Bridelia retusa is an indigenous medicinal plants belonging to family Euphorbiaceae and are used in the treatment of various disorders such as inflammation, kidney stones, urinary disorders, diarrhoea and dysentery. The stem bark of Bridelia retusa was subjected for macro and microscopical analysis, various physico chemical standardisation parameters and phytochemical studies according to Indian Pharmacopoeia. Total phenolic and flavonoid content were estimated using standard procedures. Cytotoxicity screening of methanol extract of Bridelia retusa was performed in Vero cells by sulforhodamine assay. The present study provides standardisation parameters for Bridelia retusa which will aid in the proper identification and authentication of the plant. Further, results of cytotoxicity screening revealed that plant exhibits no toxicity even at higher concentration and IC50 was found to be 430.6 μg/ml.",
author = "Xavier, {Seena Kanniparambil} and Sankaran, {Praveen Kallamvalliillam} and Ananad, {Devkar Raviraj} and Shreedhara, {Chandrasekhara Shastry} and Setty, {Manganahally Manjunath}",
year = "2017",
month = "3",
day = "1",
doi = "10.1166/asl.2017.8500",
language = "English",
volume = "23",
pages = "1773--1776",
journal = "Advanced Science Letters",
issn = "1936-6612",
publisher = "American Scientific Publishers",
number = "3",

}

Pharmacognostical standardisation and cytotoxicity screening of Bridelia retusa spreng. / Xavier, Seena Kanniparambil; Sankaran, Praveen Kallamvalliillam; Ananad, Devkar Raviraj; Shreedhara, Chandrasekhara Shastry; Setty, Manganahally Manjunath.

In: Advanced Science Letters, Vol. 23, No. 3, 01.03.2017, p. 1773-1776.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pharmacognostical standardisation and cytotoxicity screening of Bridelia retusa spreng

AU - Xavier, Seena Kanniparambil

AU - Sankaran, Praveen Kallamvalliillam

AU - Ananad, Devkar Raviraj

AU - Shreedhara, Chandrasekhara Shastry

AU - Setty, Manganahally Manjunath

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Bridelia retusa is an indigenous medicinal plants belonging to family Euphorbiaceae and are used in the treatment of various disorders such as inflammation, kidney stones, urinary disorders, diarrhoea and dysentery. The stem bark of Bridelia retusa was subjected for macro and microscopical analysis, various physico chemical standardisation parameters and phytochemical studies according to Indian Pharmacopoeia. Total phenolic and flavonoid content were estimated using standard procedures. Cytotoxicity screening of methanol extract of Bridelia retusa was performed in Vero cells by sulforhodamine assay. The present study provides standardisation parameters for Bridelia retusa which will aid in the proper identification and authentication of the plant. Further, results of cytotoxicity screening revealed that plant exhibits no toxicity even at higher concentration and IC50 was found to be 430.6 μg/ml.

AB - Bridelia retusa is an indigenous medicinal plants belonging to family Euphorbiaceae and are used in the treatment of various disorders such as inflammation, kidney stones, urinary disorders, diarrhoea and dysentery. The stem bark of Bridelia retusa was subjected for macro and microscopical analysis, various physico chemical standardisation parameters and phytochemical studies according to Indian Pharmacopoeia. Total phenolic and flavonoid content were estimated using standard procedures. Cytotoxicity screening of methanol extract of Bridelia retusa was performed in Vero cells by sulforhodamine assay. The present study provides standardisation parameters for Bridelia retusa which will aid in the proper identification and authentication of the plant. Further, results of cytotoxicity screening revealed that plant exhibits no toxicity even at higher concentration and IC50 was found to be 430.6 μg/ml.

UR - http://www.scopus.com/inward/record.url?scp=85018609423&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018609423&partnerID=8YFLogxK

U2 - 10.1166/asl.2017.8500

DO - 10.1166/asl.2017.8500

M3 - Article

VL - 23

SP - 1773

EP - 1776

JO - Advanced Science Letters

JF - Advanced Science Letters

SN - 1936-6612

IS - 3

ER -