Pharmacognostical standardisation and cytotoxicity screening of Bridelia retusa spreng

Seena Kanniparambil Xavier, Praveen Kallamvalliillam Sankaran, Devkar Raviraj Ananad, Chandrasekhara Shastry Shreedhara, Manganahally Manjunath Setty

Research output: Contribution to journalArticle

Abstract

Bridelia retusa is an indigenous medicinal plants belonging to family Euphorbiaceae and are used in the treatment of various disorders such as inflammation, kidney stones, urinary disorders, diarrhoea and dysentery. The stem bark of Bridelia retusa was subjected for macro and microscopical analysis, various physico chemical standardisation parameters and phytochemical studies according to Indian Pharmacopoeia. Total phenolic and flavonoid content were estimated using standard procedures. Cytotoxicity screening of methanol extract of Bridelia retusa was performed in Vero cells by sulforhodamine assay. The present study provides standardisation parameters for Bridelia retusa which will aid in the proper identification and authentication of the plant. Further, results of cytotoxicity screening revealed that plant exhibits no toxicity even at higher concentration and IC50 was found to be 430.6 μg/ml.

Original languageEnglish
Pages (from-to)1773-1776
Number of pages4
JournalAdvanced Science Letters
Volume23
Issue number3
DOIs
Publication statusPublished - 01-03-2017

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All Science Journal Classification (ASJC) codes

  • Health(social science)
  • Computer Science(all)
  • Education
  • Mathematics(all)
  • Environmental Science(all)
  • Engineering(all)
  • Energy(all)

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