Pharmacokinetic evaluation of surfactant vesicle-entrapped methotrexate in tumor-bearing mice

K. S. Chandraprakash, N. Udupa, P. Umadevi, G. K. Pillai

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Abstract

Methotrexate was encapsulated in niosomes. The entrapment efficiency increased with increase in lipophilicity of surfactant. Unilamellar vesicles prepared with span 60 showed maximum entrapment and its pharmacokinetics in mice transplanted with S-180 tumor was markedly different in comparison to unentrapped methotrexate.

Original languageEnglish
JournalInternational Journal of Pharmaceutics
Volume61
Issue number1-2
DOIs
Publication statusPublished - 11-06-1990

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All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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