Pharmacokinetic evaluation of surfactant vesicle-entrapped methotrexate in tumor-bearing mice

K. S. Chandraprakash, N. Udupa, P. Umadevi, G. K. Pillai

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Methotrexate was encapsulated in niosomes. The entrapment efficiency increased with increase in lipophilicity of surfactant. Unilamellar vesicles prepared with span 60 showed maximum entrapment and its pharmacokinetics in mice transplanted with S-180 tumor was markedly different in comparison to unentrapped methotrexate.

Original languageEnglish
JournalInternational Journal of Pharmaceutics
Volume61
Issue number1-2
DOIs
Publication statusPublished - 11-06-1990

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Methotrexate
Surface-Active Agents
Pharmacokinetics
Unilamellar Liposomes
Liposomes
Neoplasms
sorbitan monostearate

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

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Pharmacokinetic evaluation of surfactant vesicle-entrapped methotrexate in tumor-bearing mice. / Chandraprakash, K. S.; Udupa, N.; Umadevi, P.; Pillai, G. K.

In: International Journal of Pharmaceutics, Vol. 61, No. 1-2, 11.06.1990.

Research output: Contribution to journalArticle

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AU - Udupa, N.

AU - Umadevi, P.

AU - Pillai, G. K.

PY - 1990/6/11

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AB - Methotrexate was encapsulated in niosomes. The entrapment efficiency increased with increase in lipophilicity of surfactant. Unilamellar vesicles prepared with span 60 showed maximum entrapment and its pharmacokinetics in mice transplanted with S-180 tumor was markedly different in comparison to unentrapped methotrexate.

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