TY - JOUR
T1 - Pharmacokinetic evaluation of surfactant vesicle-entrapped methotrexate in tumor-bearing mice
AU - Chandraprakash, K. S.
AU - Udupa, N.
AU - Umadevi, P.
AU - Pillai, G. K.
PY - 1990/6/11
Y1 - 1990/6/11
N2 - Methotrexate was encapsulated in niosomes. The entrapment efficiency increased with increase in lipophilicity of surfactant. Unilamellar vesicles prepared with span 60 showed maximum entrapment and its pharmacokinetics in mice transplanted with S-180 tumor was markedly different in comparison to unentrapped methotrexate.
AB - Methotrexate was encapsulated in niosomes. The entrapment efficiency increased with increase in lipophilicity of surfactant. Unilamellar vesicles prepared with span 60 showed maximum entrapment and its pharmacokinetics in mice transplanted with S-180 tumor was markedly different in comparison to unentrapped methotrexate.
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U2 - 10.1016/0378-5173(90)90056-A
DO - 10.1016/0378-5173(90)90056-A
M3 - Article
AN - SCOPUS:0025314159
SN - 0378-5173
VL - 61
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1-2
ER -