Pharmacological potential of some novel quinazolin-4(3H)-ones

J.E. Mathew, V. Dinakaran, N. Kaur, K.K. Srinivasan

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2 Citations (Scopus)

Abstract

In present study some novel derivatives of 2-(N-substituted amino) methyl-3-(4-chlorophenyl)-quinazolin-4(3H)-ones have been synthesized by the condensation of respective 6, 8-disubstituted-2-chloromethyl-3-(4-chlorophenyl)-quinazolin-4-(3H) ones with different primary amines in equi molar concentrations. The structures of these compounds have been established on the basis of their spectral data. These compounds were tested for anti-inflammatory and antimicrobial potentials by carrageenan-induced rat paw oedema model and cup-plate method respectively, Compound 3-(4-chlorophenyl)-2-[(3-hydroxy phenyl amino)-methyl]-3h-quinazolin-4-one (QN03) showed comparable anti-inflammatory activity with the standard drug used and also showed good antibacterial activity. Other compounds exhibited mild to moderate antibacterial activity.
Original languageEnglish
Pages (from-to)618-623
Number of pages6
JournalPharmacologyonline
Volume2
Publication statusPublished - 2008

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    Mathew, J. E., Dinakaran, V., Kaur, N., & Srinivasan, K. K. (2008). Pharmacological potential of some novel quinazolin-4(3H)-ones. Pharmacologyonline, 2, 618-623.