Phenol red inhibits arsenate uptake by the everted gut sacs of mice and reduces its toxicity

R. Latha, Rashmi P. Rao, J. Prakasa Rao

Research output: Contribution to journalArticle

Abstract

Uptake of arsenate by the everted intestinal sac of mice was found to be reduced by phenol red. Presence of the dye on the serosal side was more effective. The intestinal damage assessed by the leakage of LDH and the level of lactate, was also lessened by the presence of phenol red. Chronic administration of arsenic was found to cause an increase in LPO and a decrease in SOD levels in many organs. Simultaneous administration of the dye significantly reduced the LPO in the intestines, kidney, and liver of the arsenate treated animals. However, the decrease in SOD activity was restored to normal by phenol red in all the organs tested in the arsenate treated animals. These findings suggest that phenol red is capable of reducing arsenate toxicity in mice.

Original languageEnglish
Pages (from-to)677-696
Number of pages20
JournalPharmacologyonline
Volume3
Publication statusPublished - 01-12-2010
Externally publishedYes

Fingerprint

Phenolsulfonphthalein
Coloring Agents
Arsenic
Intestines
Lactic Acid
Kidney
arsenic acid
Liver

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

Latha, R. ; Rao, Rashmi P. ; Prakasa Rao, J. / Phenol red inhibits arsenate uptake by the everted gut sacs of mice and reduces its toxicity. In: Pharmacologyonline. 2010 ; Vol. 3. pp. 677-696.
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Phenol red inhibits arsenate uptake by the everted gut sacs of mice and reduces its toxicity. / Latha, R.; Rao, Rashmi P.; Prakasa Rao, J.

In: Pharmacologyonline, Vol. 3, 01.12.2010, p. 677-696.

Research output: Contribution to journalArticle

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