Phenytoin and phenobarbital

A comparison of their state-dependent effects

K. B. Kumar, S. Ramalingam, K. Sudhakar Karanth

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Two commonly used antiepileptic drugs, phenytoin sodium and phenobarbital sodium, were investigated for state-dependency effects at different doses. Male Wistar strain rats trained to a criterion in an inhibitory avoidance task and a food-motivated T-maze task under varying drug and nondrug states were subjected to retention tests 24 and 48 h, respectively, following acquisition. The treatment instituted at the time of retrieval was either the same as, or different from, that used during training. The results indicated that phenytoin produced state-dependency effects at test doses of 20, 40, and 60 mg/kg in the avoidance task and at test dose of 20 mg/kg in the T-maze task experiments. These state-specific effects were comparable to those of phenobarbital sodium (5 and 10 mg/kg). The reinstitution of the drug state in an additional test session produced approximately equal and significant recovery of conditioned responses in the T-maze paradigm both in phenytoin and phenobarbital groups. These results demonstrate, for the first time, the ability of phenytoin to produce state-dependency effects in a pattern similar to that observed with a widely studied compound such as phenobarbital. Overall, the data provide no support for the view that the degree of discriminability of a drug is an indicator of potential state-dependency effects and is restricted only to the dosage high enough to produce noticeable intoxication.

Original languageEnglish
Pages (from-to)951-956
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume47
Issue number4
DOIs
Publication statusPublished - 01-01-1994
Externally publishedYes

Fingerprint

Phenytoin
Phenobarbital
Pharmaceutical Preparations
Anticonvulsants
Wistar Rats
Rats
Recovery
Food
Experiments

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Kumar, K. B. ; Ramalingam, S. ; Sudhakar Karanth, K. / Phenytoin and phenobarbital : A comparison of their state-dependent effects. In: Pharmacology, Biochemistry and Behavior. 1994 ; Vol. 47, No. 4. pp. 951-956.
@article{6e241f84e3bd4ee2bf0c7b6df11c7353,
title = "Phenytoin and phenobarbital: A comparison of their state-dependent effects",
abstract = "Two commonly used antiepileptic drugs, phenytoin sodium and phenobarbital sodium, were investigated for state-dependency effects at different doses. Male Wistar strain rats trained to a criterion in an inhibitory avoidance task and a food-motivated T-maze task under varying drug and nondrug states were subjected to retention tests 24 and 48 h, respectively, following acquisition. The treatment instituted at the time of retrieval was either the same as, or different from, that used during training. The results indicated that phenytoin produced state-dependency effects at test doses of 20, 40, and 60 mg/kg in the avoidance task and at test dose of 20 mg/kg in the T-maze task experiments. These state-specific effects were comparable to those of phenobarbital sodium (5 and 10 mg/kg). The reinstitution of the drug state in an additional test session produced approximately equal and significant recovery of conditioned responses in the T-maze paradigm both in phenytoin and phenobarbital groups. These results demonstrate, for the first time, the ability of phenytoin to produce state-dependency effects in a pattern similar to that observed with a widely studied compound such as phenobarbital. Overall, the data provide no support for the view that the degree of discriminability of a drug is an indicator of potential state-dependency effects and is restricted only to the dosage high enough to produce noticeable intoxication.",
author = "Kumar, {K. B.} and S. Ramalingam and {Sudhakar Karanth}, K.",
year = "1994",
month = "1",
day = "1",
doi = "10.1016/0091-3057(94)90302-6",
language = "English",
volume = "47",
pages = "951--956",
journal = "Pharmacology Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "4",

}

Phenytoin and phenobarbital : A comparison of their state-dependent effects. / Kumar, K. B.; Ramalingam, S.; Sudhakar Karanth, K.

In: Pharmacology, Biochemistry and Behavior, Vol. 47, No. 4, 01.01.1994, p. 951-956.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Phenytoin and phenobarbital

T2 - A comparison of their state-dependent effects

AU - Kumar, K. B.

AU - Ramalingam, S.

AU - Sudhakar Karanth, K.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Two commonly used antiepileptic drugs, phenytoin sodium and phenobarbital sodium, were investigated for state-dependency effects at different doses. Male Wistar strain rats trained to a criterion in an inhibitory avoidance task and a food-motivated T-maze task under varying drug and nondrug states were subjected to retention tests 24 and 48 h, respectively, following acquisition. The treatment instituted at the time of retrieval was either the same as, or different from, that used during training. The results indicated that phenytoin produced state-dependency effects at test doses of 20, 40, and 60 mg/kg in the avoidance task and at test dose of 20 mg/kg in the T-maze task experiments. These state-specific effects were comparable to those of phenobarbital sodium (5 and 10 mg/kg). The reinstitution of the drug state in an additional test session produced approximately equal and significant recovery of conditioned responses in the T-maze paradigm both in phenytoin and phenobarbital groups. These results demonstrate, for the first time, the ability of phenytoin to produce state-dependency effects in a pattern similar to that observed with a widely studied compound such as phenobarbital. Overall, the data provide no support for the view that the degree of discriminability of a drug is an indicator of potential state-dependency effects and is restricted only to the dosage high enough to produce noticeable intoxication.

AB - Two commonly used antiepileptic drugs, phenytoin sodium and phenobarbital sodium, were investigated for state-dependency effects at different doses. Male Wistar strain rats trained to a criterion in an inhibitory avoidance task and a food-motivated T-maze task under varying drug and nondrug states were subjected to retention tests 24 and 48 h, respectively, following acquisition. The treatment instituted at the time of retrieval was either the same as, or different from, that used during training. The results indicated that phenytoin produced state-dependency effects at test doses of 20, 40, and 60 mg/kg in the avoidance task and at test dose of 20 mg/kg in the T-maze task experiments. These state-specific effects were comparable to those of phenobarbital sodium (5 and 10 mg/kg). The reinstitution of the drug state in an additional test session produced approximately equal and significant recovery of conditioned responses in the T-maze paradigm both in phenytoin and phenobarbital groups. These results demonstrate, for the first time, the ability of phenytoin to produce state-dependency effects in a pattern similar to that observed with a widely studied compound such as phenobarbital. Overall, the data provide no support for the view that the degree of discriminability of a drug is an indicator of potential state-dependency effects and is restricted only to the dosage high enough to produce noticeable intoxication.

UR - http://www.scopus.com/inward/record.url?scp=0028333844&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028333844&partnerID=8YFLogxK

U2 - 10.1016/0091-3057(94)90302-6

DO - 10.1016/0091-3057(94)90302-6

M3 - Article

VL - 47

SP - 951

EP - 956

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

IS - 4

ER -