This chapter describes various aspects of photobiomodulation in tissue repair and regeneration. The multifaceted process of wound healing proceeds through distinct and overlapping phases, namely haemostasis, inflammation, proliferation, and remodeling. In recent past, management of chronic injuries or non-healing wounds has been the greatest challenge especially in burn injuries or diabetic ulcers wherein complications like infection, and fluid loss could increase the risk of mortality. Recent advances in the field of biophotonics has led to the era of next-generation therapeutics, wherein light has been exploited to alter biochemical changes at cellular levels, and the phenomenon is commonly referred to as "Photobiomodulation"(PBM). Although PBM therapy tried and tested for the treatment of various ailments, current chapter focuses mainly on application of this therapy on different types of wounds. Basics of lowlevel laser therapy, light tissue interaction; different illumination parameters involved in PBM therapy are discussed. Pre-clinical and clinical studies utilizing LLLT for treatment of acute, diabetic and burn wounds in last five years are also discussed. Mechanisms underlying positive effects of LLLT in tissue repair and regeneration are documented. Recent literature highlighting the pitfalls of earlier reports and suggesting the newer model for understating the mechanism of PBM therapy are also been reviewed in this chapter.
|Title of host publication||Laser Therapies|
|Subtitle of host publication||Types, Uses and Safety|
|Publisher||Nova Science Publishers, Inc.|
|Number of pages||28|
|Publication status||Published - 08-01-2020|
All Science Journal Classification (ASJC) codes
- Physics and Astronomy(all)