Photobiomodulatory effects of He-Ne laser on excision wounds

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Abstract

Presently, great importance has been given to Low Level Laser Therapy (LLLT) with the intent of promoting wound healing process. The present study was aimed to investigate the promotive effect of LLLT on full thickness excision wounds in Swiss albino mice using optical fiber probe based light device. Circular wounds of diameter 15 mm were illuminated with single exposure of various laser doses 1, 2, 3, 4, 6, 8 and 10 J/cm2 along with appropriate controls. Further, an optimal dose of 2 J/cm2 was applied to excision wounds at different post-wounding treatment schedules (0, 24 h and 48 h) to explicate the relations between treatment schedule and its tissue regeneration potential. Wound area, mean wound healing time along with hydroxyproline and glucosamine levels from wound ground tissue was assessed to evaluate the resultant photobiostimulatory outcome. Histological analysis was performed on day 10 of post-wounding. A significant increase in hydroxyproline (P< 0.001) and glucosamine levels (P< 0.01) were observed in 2 J/cm 2 irradiation group, which was also substantiated by histological findings. In conclusion, the present study demonstrated that the immediate irradiation of 2 J/cm2 dose following wounding hasten the healing process compared to the unilluminated control.

Original languageEnglish
Title of host publicationMechanisms for Low-Light Therapy VI
Volume7887
DOIs
Publication statusPublished - 2011
EventMechanisms for Low-Light Therapy IX - San Francisco, CA, United States
Duration: 01-02-201402-02-2014

Conference

ConferenceMechanisms for Low-Light Therapy IX
CountryUnited States
CitySan Francisco, CA
Period01-02-1402-02-14

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All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Prabhu, V., Rao, S. B. S., Kumar, P., Rao, L., & Mahato, K. K. (2011). Photobiomodulatory effects of He-Ne laser on excision wounds. In Mechanisms for Low-Light Therapy VI (Vol. 7887). [78870H] https://doi.org/10.1117/12.874814