Photosensitive surfactants with various hydrophobic tail lengths for the photocontrol of genomic DNA conformation with improved efficiency

Antoine Diguet, Naresh Kumar Mani, Marie Geoffroy, Matthieu Sollogoub, Damien Baigl

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56 Citations (Scopus)

Abstract

We report the synthesis and characterisation of photosensitive cationic surfactants with various hydrophobic tail lengths. These molecules, called AzoCx, are used as photosensitive nucleic acid binders (pNABs) and are applied to the photocontrol of DNA conformation. All these molecules induce DNA compaction in a photodependent way, originating in the photodependent polarity of their hydrophobic tails. We show that increasing hydrophobicity strongly enhances the compaction efficiencies of these molecules, but reduces the possibility of reversible photocontrol of a DNA conformation. Optimal performance was achieved with AzoC5, which allowed reversible control of DNA conformation with light at a concentration seven times smaller than previously reported. Photocontrol: The synthesis and characterisation of photosensitive cationic surfactants with varying hydrophobic tail lengths (AzoCx) for the photocontrol of DNA conformation is described. These molecules induce photodependent DNA compaction, originating in the photodependent polarities of their hydrophobic tails. Optimum performance was achieved with AzoC5, which allowed reversible control of DNA conformation with light at a concentration seven times smaller than previously reported (see figure).

Original languageEnglish
Pages (from-to)11890-11896
Number of pages7
JournalChemistry - A European Journal
Volume16
Issue number39
DOIs
Publication statusPublished - 18-10-2010

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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