Physicochemical and biological studies of inclusion complex of methotrexate with β-cyclodextrin

U.V. Singh, K.S. Aithal, N. Udupa

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Methotrexate forms an inclusion complex with β-cyclodextrin (β-CyD) by a neutralization method. The formation of the inclusion complex was studied by phase solubility, X-ray diffractometry, differential scanning calorimetry and infrared spectroscopy. The amino group of methotrexate interacted with the hydroxyl function of β-CyD on complexation. The in-vitro drug release from the complex in phosphate buffer, pH-7.2, was better than that of the plain drug and other preparations evaluated. The complex had better bioavailability and showed better antitumour efficacy than methotrexate alone.
Original languageUndefined/Unknown
Pages (from-to)573-577
Number of pages5
JournalPharmaceutical Sciences
Volume3
Issue number12
Publication statusPublished - 1997

Cite this

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title = "Physicochemical and biological studies of inclusion complex of methotrexate with β-cyclodextrin",
abstract = "Methotrexate forms an inclusion complex with β-cyclodextrin (β-CyD) by a neutralization method. The formation of the inclusion complex was studied by phase solubility, X-ray diffractometry, differential scanning calorimetry and infrared spectroscopy. The amino group of methotrexate interacted with the hydroxyl function of β-CyD on complexation. The in-vitro drug release from the complex in phosphate buffer, pH-7.2, was better than that of the plain drug and other preparations evaluated. The complex had better bioavailability and showed better antitumour efficacy than methotrexate alone.",
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Physicochemical and biological studies of inclusion complex of methotrexate with β-cyclodextrin. / Singh, U.V.; Aithal, K.S.; Udupa, N.

In: Pharmaceutical Sciences, Vol. 3, No. 12, 1997, p. 573-577.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Physicochemical and biological studies of inclusion complex of methotrexate with β-cyclodextrin

AU - Singh, U.V.

AU - Aithal, K.S.

AU - Udupa, N.

N1 - cited By 8

PY - 1997

Y1 - 1997

N2 - Methotrexate forms an inclusion complex with β-cyclodextrin (β-CyD) by a neutralization method. The formation of the inclusion complex was studied by phase solubility, X-ray diffractometry, differential scanning calorimetry and infrared spectroscopy. The amino group of methotrexate interacted with the hydroxyl function of β-CyD on complexation. The in-vitro drug release from the complex in phosphate buffer, pH-7.2, was better than that of the plain drug and other preparations evaluated. The complex had better bioavailability and showed better antitumour efficacy than methotrexate alone.

AB - Methotrexate forms an inclusion complex with β-cyclodextrin (β-CyD) by a neutralization method. The formation of the inclusion complex was studied by phase solubility, X-ray diffractometry, differential scanning calorimetry and infrared spectroscopy. The amino group of methotrexate interacted with the hydroxyl function of β-CyD on complexation. The in-vitro drug release from the complex in phosphate buffer, pH-7.2, was better than that of the plain drug and other preparations evaluated. The complex had better bioavailability and showed better antitumour efficacy than methotrexate alone.

M3 - Article

VL - 3

SP - 573

EP - 577

JO - Pharmaceutical Sciences

JF - Pharmaceutical Sciences

SN - 1735-403X

IS - 12

ER -