Phytosynthesis of gold nanoparticles: Characterization, biocompatibility, and evaluation of its osteoinductive potential for application in implant dentistry

Kiran Jadhav, Rajeshwari HR, Swapnil Deshpande, Satveer Jagwani, Dinesh Dhamecha, Sunil Jalalpure, Karthikeyan Subburayan, Dwarkadas Baheti

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Gold nanoparticles have been extensively used in diagnostics, biomedical imaging, and drug delivery owing to simple method of synthesis and versatile surface functionalization. Present investigation aims to evaluate the osteoinductive property of Salacia chinensis (SC) mediated gold nanoparticles (GNPs) for its application in implant dentistry. The formation of GNPs was assessed initially using the visual method and characterized analytically by using UV–visible spectroscopy, Zetasizer, X-RD, ICP-AES, AFM, and TEM. Green synthesized GNPs exhibited a remarkable stability in various blood components (0.2 M histidine, 0.2 M cysteine 2% bovine serum albumin, and 2% human serum albumin) and were found to be nontoxic when evaluated for their cytocompatibility and blood compatibility using periodontal fibroblasts and erythrocytes respectively. Exposure of GNPs to MG-63 cell lines displayed increased percent cell viability (138 ± 27.4) compared to the control group (96 ± 3.7) which confirms its osteoinductive potential. Herein, it can be concluded that the stable, biocompatible and eco-friendly GNPs can be used as an effective bone inductive agent during dental implant therapy.

Original languageEnglish
Pages (from-to)664-670
Number of pages7
JournalMaterials Science and Engineering C
Volume93
DOIs
Publication statusPublished - 01-12-2018

Fingerprint

dentistry
Dentistry
biocompatibility
Biocompatibility
Gold
gold
Nanoparticles
nanoparticles
evaluation
albumins
serums
blood
Salacia
Blood
Cells
Myeloma Proteins
Dental prostheses
histidine
cysteine
fibroblasts

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Jadhav, Kiran ; HR, Rajeshwari ; Deshpande, Swapnil ; Jagwani, Satveer ; Dhamecha, Dinesh ; Jalalpure, Sunil ; Subburayan, Karthikeyan ; Baheti, Dwarkadas. / Phytosynthesis of gold nanoparticles : Characterization, biocompatibility, and evaluation of its osteoinductive potential for application in implant dentistry. In: Materials Science and Engineering C. 2018 ; Vol. 93. pp. 664-670.
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Phytosynthesis of gold nanoparticles : Characterization, biocompatibility, and evaluation of its osteoinductive potential for application in implant dentistry. / Jadhav, Kiran; HR, Rajeshwari; Deshpande, Swapnil; Jagwani, Satveer; Dhamecha, Dinesh; Jalalpure, Sunil; Subburayan, Karthikeyan; Baheti, Dwarkadas.

In: Materials Science and Engineering C, Vol. 93, 01.12.2018, p. 664-670.

Research output: Contribution to journalArticle

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AU - Jadhav, Kiran

AU - HR, Rajeshwari

AU - Deshpande, Swapnil

AU - Jagwani, Satveer

AU - Dhamecha, Dinesh

AU - Jalalpure, Sunil

AU - Subburayan, Karthikeyan

AU - Baheti, Dwarkadas

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