PKa determination of carvedilol by spectrophotometry

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Abstract

Proper knowledge of the pKa value of a compound is of uttermost importance for understanding the behavior of a drug inside the body. The pKa value of Nonselective alpha-1 and beta-blocker Carvedilol shows controversies in literature, whereas values between 7.7 and 8.7 have been previously reported. In this research paper, the pKa value of Carvedilol was re-evaluated using UV-vis spectroscopy. The analytical wavelength used was 241nm. The obtained sigmoid pattern was non-linear fitted using the Boltzmann sigmoidal algorithm. The determined pKa was 7.77 ± 0.09. This value is in accordance with some of the literature publications. Since extensive statistics and multiple replicate experiments were performed, it is assumed that 7.8 is the true pKa value of Carvedilol. Instruments: Digital pH meter MK VI, Systronics Limited, Ahmedabad – 380013, India. UV-Vis spectrophotometer of model UV-2450, Shimadzu Analytical, New Delhi – 110082, India, Cat. No. 208-24301-93.

Original languageEnglish
Pages (from-to)2714-2716
Number of pages3
JournalResearch Journal of Pharmacy and Technology
Volume14
Issue number5
DOIs
Publication statusPublished - 05-2021

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
  • Pharmacology (medical)

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