Plasma adenosine deaminase activity and antioxidant status in preeclampsia compared to healthy pregnant and nonpregnant women

M. S. Rukmini, R. Kowsalya, B. Pai, P. Das, J. Perriera, M. Nandini, K. Asha

Research output: Contribution to journalArticle

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Abstract

Preeclampsia is a multisystemic disorder specific to human pregnancy. It is common and major complication, characterized by hypertension, proteinuria and oedema. This clinical condition adversely affects the mother and the foetus. The causative factors remain poorly understood. Oxidative stress is implicated in preeclampsia which could provide the linkage between decreased placental perfusion and the maternal syndrome. Pregnancy has also been associated with depressed cell mediated immunity. The increase in activity of adenosine deaminase (ADA) in preeclamptic women compared to normotensive pregnant women is reported in earlier studies. The main objective of the present study was to correlate the adenosine deaminase activity with the antioxidant status in preeclamptic patients. The study groups aged between 20 - 35 years included 20 normotensive primigravida women and 20 primigravida diagnosed as preeclampsia in their last trimester. The control group included 20 healthy nonpregnant women volunteers of the same age group. The diagnosis of preeclampsia was made by a gynecologist at Lady Goshen Hospital. The adenosine deaminase activity and antioxidant status in the form of superoxide dismutase (SOD), glutathione (GSH) and total antioxidant activity (TAA) were measured. The extent of oxidative stress was estimated by measuring plasma malondialdehyde (MDA) levels. The comparison of MDA between controls and preeclamptic patients showed significance (p 0.000). The total antioxidant activity (TAA) between the controls and preeclamptic patients showed significance (p 0.000). However, ADA activity did not show statistical significance among the different study groups. The ADA activity may not be significant due to other systemic causes such as anemia and malnutrition.

Original languageEnglish
Pages (from-to)15-20
Number of pages6
JournalBiomedical Research
Volume20
Issue number1
Publication statusPublished - 2009

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Adenosine Deaminase
Pre-Eclampsia
Pregnant Women
Antioxidants
Plasmas
Oxidative stress
Malondialdehyde
Oxidative Stress
Mothers
Pregnancy
Third Pregnancy Trimester
Proteinuria
Cellular Immunity
Malnutrition
Superoxide Dismutase
Glutathione
Anemia
Volunteers
Edema
Fetus

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Plasma adenosine deaminase activity and antioxidant status in preeclampsia compared to healthy pregnant and nonpregnant women",
abstract = "Preeclampsia is a multisystemic disorder specific to human pregnancy. It is common and major complication, characterized by hypertension, proteinuria and oedema. This clinical condition adversely affects the mother and the foetus. The causative factors remain poorly understood. Oxidative stress is implicated in preeclampsia which could provide the linkage between decreased placental perfusion and the maternal syndrome. Pregnancy has also been associated with depressed cell mediated immunity. The increase in activity of adenosine deaminase (ADA) in preeclamptic women compared to normotensive pregnant women is reported in earlier studies. The main objective of the present study was to correlate the adenosine deaminase activity with the antioxidant status in preeclamptic patients. The study groups aged between 20 - 35 years included 20 normotensive primigravida women and 20 primigravida diagnosed as preeclampsia in their last trimester. The control group included 20 healthy nonpregnant women volunteers of the same age group. The diagnosis of preeclampsia was made by a gynecologist at Lady Goshen Hospital. The adenosine deaminase activity and antioxidant status in the form of superoxide dismutase (SOD), glutathione (GSH) and total antioxidant activity (TAA) were measured. The extent of oxidative stress was estimated by measuring plasma malondialdehyde (MDA) levels. The comparison of MDA between controls and preeclamptic patients showed significance (p 0.000). The total antioxidant activity (TAA) between the controls and preeclamptic patients showed significance (p 0.000). However, ADA activity did not show statistical significance among the different study groups. The ADA activity may not be significant due to other systemic causes such as anemia and malnutrition.",
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Plasma adenosine deaminase activity and antioxidant status in preeclampsia compared to healthy pregnant and nonpregnant women. / Rukmini, M. S.; Kowsalya, R.; Pai, B.; Das, P.; Perriera, J.; Nandini, M.; Asha, K.

In: Biomedical Research, Vol. 20, No. 1, 2009, p. 15-20.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Plasma adenosine deaminase activity and antioxidant status in preeclampsia compared to healthy pregnant and nonpregnant women

AU - Rukmini, M. S.

AU - Kowsalya, R.

AU - Pai, B.

AU - Das, P.

AU - Perriera, J.

AU - Nandini, M.

AU - Asha, K.

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