Plasma protein oxidation in patients with brain tumors

Prem Kumar, Uma Devi, Sabir Ali, Ramya Upadhya, Sailaja Pillai, Annaswamy Raja, Suryanarayana Rao, Anjali Rao

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: Proteins can undergo numerous covalent changes on exposure to oxidants. Oxidative modification of protein in vivo may affect a variety of cellular functions. Protein oxidation in vivo is a natural consequence of aerobic life. Oxygen radicals and other activated oxygen species generated as byproducts of cellular metabolism or from environmental sources cause modifications to the amino acids of proteins that generally result in loss of protein function/enzymatic activity. It is now well known that reactive oxygen species (ROS) play a key role in human cancer development. Moreover, the brain is especially vulnerable to ROS mediated injury. Method: Therefore, in the present study, protein oxidation was assessed in the plasma of 17 patients with brain tumors and 16 age and gender-matched controls by measuring protein thiols and protein carbonyls spectrophotometrically. Results: There was a significant decrease in protein thiols and carbonyls in malignant cases of brain tumors when compared with the control group. No significant change in protein thiols was noted in benign cases compared to controls. A comparison of levels in benign and malignant cases for both the parameters also showed no significant difference. Discussion: Thus, free radical toxicity does lead to protein oxidation in patients with brain tumors.

Original languageEnglish
Pages (from-to)270-273
Number of pages4
JournalNeurological Research
Volume31
Issue number3
DOIs
Publication statusPublished - 01-04-2009
Externally publishedYes

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Brain Neoplasms
Blood Proteins
Proteins
Sulfhydryl Compounds
Reactive Oxygen Species
Human Development
Oxidants
Free Radicals
Oxygen
Amino Acids
Control Groups
Wounds and Injuries
Brain

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Kumar, P., Devi, U., Ali, S., Upadhya, R., Pillai, S., Raja, A., ... Rao, A. (2009). Plasma protein oxidation in patients with brain tumors. Neurological Research, 31(3), 270-273. https://doi.org/10.1179/174313209X382296
Kumar, Prem ; Devi, Uma ; Ali, Sabir ; Upadhya, Ramya ; Pillai, Sailaja ; Raja, Annaswamy ; Rao, Suryanarayana ; Rao, Anjali. / Plasma protein oxidation in patients with brain tumors. In: Neurological Research. 2009 ; Vol. 31, No. 3. pp. 270-273.
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Kumar, P, Devi, U, Ali, S, Upadhya, R, Pillai, S, Raja, A, Rao, S & Rao, A 2009, 'Plasma protein oxidation in patients with brain tumors', Neurological Research, vol. 31, no. 3, pp. 270-273. https://doi.org/10.1179/174313209X382296

Plasma protein oxidation in patients with brain tumors. / Kumar, Prem; Devi, Uma; Ali, Sabir; Upadhya, Ramya; Pillai, Sailaja; Raja, Annaswamy; Rao, Suryanarayana; Rao, Anjali.

In: Neurological Research, Vol. 31, No. 3, 01.04.2009, p. 270-273.

Research output: Contribution to journalArticle

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Kumar P, Devi U, Ali S, Upadhya R, Pillai S, Raja A et al. Plasma protein oxidation in patients with brain tumors. Neurological Research. 2009 Apr 1;31(3):270-273. https://doi.org/10.1179/174313209X382296