Plasma protein thiols and total antioxidant power in pediatric nephrotic syndrome

Kadirvel Karthikeyan, Indrajit Sinha, Krishnananda Prabhu, Nalini Bhaskaranand, Anjali Rao

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Oxidative damage by free radicals has been implicated in kidney injury, especially in nephrotic syndrome (NS). Such a stress would influence the response of nephrotic children to therapy. Methods: The present study enrolled children with NS in active disease state and in remission and 50 healthy volunteers. Plasma protein thiol levels and ferric-reducing/antioxidant power were estimated spectrophotometrically in controls and in patients. Serum protein and albumin as well as urine protein were also estimated. Results: There was a significant decrease in plasma protein thiol levels in children with active disease when compared to controls as well as to subjects in remission. Ferric-reducing/antioxidant power values were significantly increased in NS and remained high in remission when compared to controls. Serum total protein and albumin were significantly decreased in nephrotics compared to controls. Further, a prospective study between the relapse and remission groups indicated a significant increase in plasma protein thiols in remission when compared to relapse exhibiting a positive response to treatment. Conclusion: A considerable alteration in the antioxidant status in NS indicates the pro-oxidant milieu existing in this condition which may have implications in the response to treatment of these patients.

Original languageEnglish
JournalNephron - Clinical Practice
Volume110
Issue number1
DOIs
Publication statusPublished - 01-09-2008
Externally publishedYes

Fingerprint

Nephrotic Syndrome
Sulfhydryl Compounds
Blood Proteins
Antioxidants
Pediatrics
Serum Albumin
Recurrence
Free Radicals
Reactive Oxygen Species
Healthy Volunteers
Therapeutics
Urine
Prospective Studies
Kidney
Wounds and Injuries
Proteins

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Karthikeyan, Kadirvel ; Sinha, Indrajit ; Prabhu, Krishnananda ; Bhaskaranand, Nalini ; Rao, Anjali. / Plasma protein thiols and total antioxidant power in pediatric nephrotic syndrome. In: Nephron - Clinical Practice. 2008 ; Vol. 110, No. 1.
@article{2c581ed8d5574095b326c60ab4805d01,
title = "Plasma protein thiols and total antioxidant power in pediatric nephrotic syndrome",
abstract = "Background: Oxidative damage by free radicals has been implicated in kidney injury, especially in nephrotic syndrome (NS). Such a stress would influence the response of nephrotic children to therapy. Methods: The present study enrolled children with NS in active disease state and in remission and 50 healthy volunteers. Plasma protein thiol levels and ferric-reducing/antioxidant power were estimated spectrophotometrically in controls and in patients. Serum protein and albumin as well as urine protein were also estimated. Results: There was a significant decrease in plasma protein thiol levels in children with active disease when compared to controls as well as to subjects in remission. Ferric-reducing/antioxidant power values were significantly increased in NS and remained high in remission when compared to controls. Serum total protein and albumin were significantly decreased in nephrotics compared to controls. Further, a prospective study between the relapse and remission groups indicated a significant increase in plasma protein thiols in remission when compared to relapse exhibiting a positive response to treatment. Conclusion: A considerable alteration in the antioxidant status in NS indicates the pro-oxidant milieu existing in this condition which may have implications in the response to treatment of these patients.",
author = "Kadirvel Karthikeyan and Indrajit Sinha and Krishnananda Prabhu and Nalini Bhaskaranand and Anjali Rao",
year = "2008",
month = "9",
day = "1",
doi = "10.1159/000148210",
language = "English",
volume = "110",
journal = "Nephron",
issn = "0028-2766",
publisher = "S. Karger AG",
number = "1",

}

Plasma protein thiols and total antioxidant power in pediatric nephrotic syndrome. / Karthikeyan, Kadirvel; Sinha, Indrajit; Prabhu, Krishnananda; Bhaskaranand, Nalini; Rao, Anjali.

In: Nephron - Clinical Practice, Vol. 110, No. 1, 01.09.2008.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Plasma protein thiols and total antioxidant power in pediatric nephrotic syndrome

AU - Karthikeyan, Kadirvel

AU - Sinha, Indrajit

AU - Prabhu, Krishnananda

AU - Bhaskaranand, Nalini

AU - Rao, Anjali

PY - 2008/9/1

Y1 - 2008/9/1

N2 - Background: Oxidative damage by free radicals has been implicated in kidney injury, especially in nephrotic syndrome (NS). Such a stress would influence the response of nephrotic children to therapy. Methods: The present study enrolled children with NS in active disease state and in remission and 50 healthy volunteers. Plasma protein thiol levels and ferric-reducing/antioxidant power were estimated spectrophotometrically in controls and in patients. Serum protein and albumin as well as urine protein were also estimated. Results: There was a significant decrease in plasma protein thiol levels in children with active disease when compared to controls as well as to subjects in remission. Ferric-reducing/antioxidant power values were significantly increased in NS and remained high in remission when compared to controls. Serum total protein and albumin were significantly decreased in nephrotics compared to controls. Further, a prospective study between the relapse and remission groups indicated a significant increase in plasma protein thiols in remission when compared to relapse exhibiting a positive response to treatment. Conclusion: A considerable alteration in the antioxidant status in NS indicates the pro-oxidant milieu existing in this condition which may have implications in the response to treatment of these patients.

AB - Background: Oxidative damage by free radicals has been implicated in kidney injury, especially in nephrotic syndrome (NS). Such a stress would influence the response of nephrotic children to therapy. Methods: The present study enrolled children with NS in active disease state and in remission and 50 healthy volunteers. Plasma protein thiol levels and ferric-reducing/antioxidant power were estimated spectrophotometrically in controls and in patients. Serum protein and albumin as well as urine protein were also estimated. Results: There was a significant decrease in plasma protein thiol levels in children with active disease when compared to controls as well as to subjects in remission. Ferric-reducing/antioxidant power values were significantly increased in NS and remained high in remission when compared to controls. Serum total protein and albumin were significantly decreased in nephrotics compared to controls. Further, a prospective study between the relapse and remission groups indicated a significant increase in plasma protein thiols in remission when compared to relapse exhibiting a positive response to treatment. Conclusion: A considerable alteration in the antioxidant status in NS indicates the pro-oxidant milieu existing in this condition which may have implications in the response to treatment of these patients.

UR - http://www.scopus.com/inward/record.url?scp=47949088815&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=47949088815&partnerID=8YFLogxK

U2 - 10.1159/000148210

DO - 10.1159/000148210

M3 - Article

VL - 110

JO - Nephron

JF - Nephron

SN - 0028-2766

IS - 1

ER -