Plumbagin-loaded PLGA microspheres with reduced toxicity and enhanced antitumour efficacy in mice

U. V. Singh, K. S. Bisht, S. Rao, P. U. Devi, N. Udupa

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Abstract

Plumbagin was encapsulated in microspheres using poly(D,L-lactide)-co-glycolide (PLGA) (50:50). The in-vitro release profile was triphasic suggesting different drug release mechanisms. The release of the drug could be controlled for about four weeks. The toxicity of plumbagin was reduced in mice after subcutaneous injection when it was encapsulated in microspheres. The volume doubling time of PLGA-loaded microspheres was significantly higher compared with the plain drug in sarcoma-180 tumour.

Original languageEnglish
Pages (from-to)407-409
Number of pages3
JournalPharmaceutical Sciences
Volume2
Issue number9
Publication statusPublished - 1996

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All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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