Polycaprolactone-based in situ implant containing curcumin-PLGA nanoparticles prepared using the multivariate technique

Narayanan Kasinathan; Muthukumar Amirthalingam; Neetinkumar D. Reddy; Meenashi B. Vanthi; Subrahmanyam M. Volety; Josyula Venkata Rao

doi:10.3109/21691401.2015.1058810

Polycaprolactone-based in situ implant containing curcumin-PLGA nanoparticles prepared using the multivariate technique

Narayanan Kasinathan, Muthukumar Amirthalingam, Neetinkumar D. Reddy, Meenashi B. Vanthi, Subrahmanyam M. Volety, Josyula Venkata Rao

Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Studies on the effect of curcumin/PLGA ratio (CPR), stabilizer (PVA) concentration, homogenization speed, homogenization time, and sonication time on mean particle size (MPS) and percentage drug encapsulation (PDE) were performed using the multivariate technique. MPS and PDE were found to be more dependent on the interaction of sonication time with the other variables. Curcumin was released in a sustained manner from curcumin-PLGA nanoparticles (CPN). CPN improved the survival rate of Ehrlich ascites carcinoma (EAC)-bearing mice and controlled the EAC-induced change in hematological parameters. Histopathology of vital organs showed that the formulation was safe. Polycaprolactone was used in preparing an in situ implant containing CPN.

Original language	English
Pages (from-to)	1520-1528
Number of pages	9
Journal	Artificial Cells, Nanomedicine and Biotechnology
Volume	44
Issue number	6
DOIs	https://doi.org/10.3109/21691401.2015.1058810
Publication status	Published - 17-08-2016

All Science Journal Classification (ASJC) codes

Biotechnology
Medicine (miscellaneous)
Biomedical Engineering
Pharmaceutical Science

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10.3109/21691401.2015.1058810

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abstract = "Studies on the effect of curcumin/PLGA ratio (CPR), stabilizer (PVA) concentration, homogenization speed, homogenization time, and sonication time on mean particle size (MPS) and percentage drug encapsulation (PDE) were performed using the multivariate technique. MPS and PDE were found to be more dependent on the interaction of sonication time with the other variables. Curcumin was released in a sustained manner from curcumin-PLGA nanoparticles (CPN). CPN improved the survival rate of Ehrlich ascites carcinoma (EAC)-bearing mice and controlled the EAC-induced change in hematological parameters. Histopathology of vital organs showed that the formulation was safe. Polycaprolactone was used in preparing an in situ implant containing CPN.",

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T1 - Polycaprolactone-based in situ implant containing curcumin-PLGA nanoparticles prepared using the multivariate technique

AU - Kasinathan, Narayanan

AU - Amirthalingam, Muthukumar

AU - Reddy, Neetinkumar D.

AU - Vanthi, Meenashi B.

AU - Volety, Subrahmanyam M.

AU - Rao, Josyula Venkata

PY - 2016/8/17

Y1 - 2016/8/17

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AB - Studies on the effect of curcumin/PLGA ratio (CPR), stabilizer (PVA) concentration, homogenization speed, homogenization time, and sonication time on mean particle size (MPS) and percentage drug encapsulation (PDE) were performed using the multivariate technique. MPS and PDE were found to be more dependent on the interaction of sonication time with the other variables. Curcumin was released in a sustained manner from curcumin-PLGA nanoparticles (CPN). CPN improved the survival rate of Ehrlich ascites carcinoma (EAC)-bearing mice and controlled the EAC-induced change in hematological parameters. Histopathology of vital organs showed that the formulation was safe. Polycaprolactone was used in preparing an in situ implant containing CPN.

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Polycaprolactone-based in situ implant containing curcumin-PLGA nanoparticles prepared using the multivariate technique

Abstract

All Science Journal Classification (ASJC) codes

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