The effect of various doses (5, 10, 20, 40, 60, 80, 100, 120, 140 and 160 mg/kg b. wt.) of 50% ethanolic extract of Septilin (a herbal preparation) was studied on the radiation-induced mortality in mice exposed to 10 Gy of γ-irradiation. Treatment of mice with different doses of Septilin, consecutively for 5 days before irradiation, delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the non-drug treated irradiated controls. All doses of Septilin provided protection against gastrointestinal (GI) deaths (death within 10 days of irradiation). However, the best protection was observed at 100 mg/kg b. wt. of Septilin, as the number of survivors after 30 days post-irradiation was highest (58.33%) in this group when compared with the other doses of Septilin. The number of survivors was 1.75 fold greater for 100 mg/kg Septilin when compared with the 2- mercaptopropionylglycine (MPG, 33.33%) which was used as a positive control. The LD50 of Septilin was 1250 mg/kg as against the optimum protective dose of 100 mg/kg. Our study demonstrates Septilin as a good radioprotective agent.
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